"Hard to believe this little tube can cause so much damage."

Zodiac is an extremely powerful and deadly liquid weapon, contained in a small vial.



The Zodiac first came into the possession of the Strategic Scientific Reserve when Agent Peggy Carter single-handedly recovered it from a band of thugs in New York City.[1]


S.H.I.E.L.D. later would label the Zodiac as having been destroyed in order to keep unfriendly factions from seeking it out.

In 2014, a terrorist cell run by a man named Baker discovered that the Zodiac still existed and stole it from S.H.I.E.L.D. with the intention of launching a terrorist strike on Willis Tower in Chicago.

The terrorists were thwarted by a S.H.I.E.L.D. STRIKE team consisting of Captain America, Black Widow and Brock Rumlow, and the Zodiac was returned to S.H.I.E.L.D. custody.[2]



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