Transhumanists are a group of humans that have evolved their bodies through cybernetic enhancements.
Transhumanists were previously prohibited from meeting publicly, under the communist regime of the Romania. It's only recently that Transhumanists have come out from meeting in each other's basements and secret locations for more public conventions and social gatherings.
Contacting Holden Radcliffe
While Hive, a powerful parasitic Inhuman was attempting to force the entire human race to evolve into semi-Inhuman creatures, agents of S.H.I.E.L.D. sought help from a scientist known as Holden Radcliffe.
In attempts to contact Radcliffe, Leo Fitz and Jemma Simmons were sent to infiltrate a social convention for emerging technologies, organized and frequented by many Transhumanists. At the convention in Bucharest, Fitz and Simmons went undercover as experimental geneticists looking to sell a new form of optic technology to Radcliffe. Unfortunately, the mission went south, as Fitz and Simmons were intercepted by Hive and other infected Inhumans. Hive left, taking Radcliffe with them.