Moore, Anderson, Scott and Mitchell of the Aryan Brotherhood steal and deliver a crate containing Lucy Bauer. In their getaway, they are attacked by Quake, who slows them down. Suddenly, Robbie Reyes drives up and transforms into Ghost Rider when Moore fires a rocket at him. He brutally murders Moore and Anderson, then kidnaps Mitchell, before getting in the Hell Charger and driving away. Johnson, who could do nothing but watch in horror, is forced to escape when the LAPD arrive.
The next day, Melinda May sends a request out to the Zephyr One to return to the Playground. Phil Coulson and Alphonso Mackenzie return as May is training a new team of specialist agents. She reveals to them details of the Ghost Rider incident, and in private, tells them Quake was there. She also reveals the officials are tracking Johnson with the intention of killing her.
Meanwhile, Johnson breaks into Scott's hospital room to question him about the crate and Ghost Rider, although he passes away. Back at the Playground, Coulson and Mack visit Leo Fitz and Jemma Simmons. Fitz gives them new equipment, including an update for Phil Coulson's Prosthetic Hand.
Fitz meets with Holden Radcliffe to watch the 2016-17 Scottish League Cup finals. However, when Radcliffe steps out of the room, Fitz discovers Aida in her new Life-Model Decoy. Fitz begins to panic because Radcliffe had built her body without permission and could get arrested.
Coulson and Mackenzie go to Canelo's Auto and Body to investigate. They find bodies brutally murdered. Reyes, suspecting they are here for the Ghost Rider, murders Mitchell, whom he's been torturing for information, to cover his tracks.
Chen opens the box with Lucy Bauer, allowing her to escape and infect him. The infection causes him to hallucinate his co-workers with demonic faces. Melinda May and the STRIKE team arrive to arrest them. Unknown to May, Bauer infects her before fleeing.
Quake, having found Robbie Reyes' location, meets him at Canelo's Auto and Body to misdirect information out of him. Reyes attempts to subdue her unsuccessfully, and Johnson reveals her powers. After questioning him, Reyes transforms into Ghost Rider and attempts to kill her. However, Johnson manages to keep herself alive, and the Rider, peeking into her soul, decides to let her live.
- Clark Gregg as Phil Coulson
- Ming-Na Wen as Melinda May
- Chloe Bennet as Daisy Johnson/Quake
- Iain De Caestecker as Leo Fitz
- Elizabeth Henstridge as Jemma Simmons
- Henry Simmons as Alphonso Mackenzie
- John Hannah as Holden Radcliffe
- Gabriel Luna as Robbie Reyes/Ghost Rider
- Natalia Cordova-Buckley as Yo-Yo Rodriguez
- Lorenzo James Henrie as Gabe Reyes
- Mallory Jansen as Aida
- Lilli Birdsell as Lucy Bauer
- Briana Venskus as Agent Piper
- Max Osinski as Agent Davis
- Ricardo Walker as Agent Prince
- Wilson Ramirez as Diego
- Jen Kuo Sung as Chen
- Samuel Barajas as Felix
- Ian Hutton as Scott
- Edward Gelhaus as Mitchell
- Blaise Miller as Agent Nathanson
- Bryan Rasmussen as Warehouse Manager
- Jerry Ying as Thug #1
- Jenson Cheng as Chen's Thug #1
- Ken DuBois as Chen's Thug #2
- Victor Chi as Chen's Thug #3
- Edwin H. Bravo as Chen's Thug #4
- Jace Jeanes as Moore (uncredited)
- Travis Wong as Zhong Wei (uncredited)
- Will Leong as Thug #2 (uncredited)
- Jed Whedon as Bus Passenger (uncredited)
- Unknown Actor as Anderson (uncredited)
- Unknown Actress as Janet (uncredited)
- Los Angeles, California
- Washington, D.C.
- West Covina, California (mentioned)
- Alhambra, California (mentioned)
- Miami, Florida (mentioned)
- Berlin, Germany (mentioned)
- Colombia (mentioned)
- Chase of Quake
- Ambush on the Chinatown Crew
- S.H.I.E.L.D. Lanyard
- Phil Coulson's Prosthetic Hand
- Exploding Pen
- Mapping-Action Eyewear
- Quantum Batteries
- Rapid Bone-Healing Pills
- Backscatter X-Ray Eye Implant
- Sokovia Accords (mentioned)
- Spirit of Vengeance (mentioned)
- Aryan Brotherhood
- Los Angeles Police Department
- Chinatown Crew
- Strategic Scientific Reserve (logo)
- Watchdogs (mentioned)
- United States Army (mentioned)
- United Nations (mentioned)
- Jeffrey Mace
- Roger Perez
- Thomas Wright
- Glenn Talbot
- Matthew Ellis
- Lincoln Campbell
- Andrew Garner
- Antoine Triplett
- Spirit of Vengeance
- Ernest Hemingway
- Aberdeen F.C.
- Inverness Caledonian Thistle F.C.
- Football League Cup
- Fast and Furious
- Dukes of Hazzard
- Uncanny Valley
- Turing test
- The opening scene where Robbie Reyes's Hell Charger is hit with an RPG, flips in the air, and lands on its wheels is a direct reference to All-New Ghost Rider #2.