During the Inhuman Outbreak, the dramatically increasing number of Inhumans developing superpowers left the authorities without a clear method of dealing with these newly gifted individual, who could be either assets or threats. S.H.I.E.L.D. having being deemed a terrorist organization due to the HYDRA Uprising, the ATCU was created. However, this new agency was also infiltrated by HYDRA and its leader Rosalind Price was killed.
Once the ATCU was cleared of its HYDRA infiltrators, American President Matthew Ellis decided to keep the agency working as S.H.I.E.L.D.'s public face. President Ellis appointed General Glenn Talbot at the head of the ATCU. However, as soon as HYDRA leader Gideon Malick learned this, he ordered Talbot's son to be kidnapped so he could blackmail the General into getting rid of S.H.I.E.L.D.
In an attempt to enforce international cooperation regarding the Inhuman Outbreak, President Ellis suggested to hold a conference named Symposium on Alien Contagion which would be hosted in Taipei, Taiwan. S.H.I.E.L.D. decided to infiltrate the symposium to find out who was working with Malick.
General Glenn Talbot joined the conference hall with Phil Coulson, who posed as Dr. Sean Lundwall, a scientist with expertise concerning Inhumans. During the reception before the actual symposium, Talbot and Coulson met with the other representatives, including Anton Petrov, Ellen King, and Xiao Chen. However, this did not help them to find Gideon Malick's associate as Talbot kept finding reasons to suspect everybody.
Talbot then welcomed the delegates into another room and officially declared the symposium open. Coulson, still acting as Dr. Lundwall, explained that the Inhumans were not a disease and that they should be treated with compassion. Russian delegate Petrov agreed and suggested to create an Inhuman Sanctuary which would be located in Russia. Although the South African representative Nathi Zuma and the Taiwanese delegate Chen were in favor of the proposal, Japanese representative Haruto Yakimura and Australian delegate King were not as enthusiastic.
Zuma proposed a vote on the subject. Before they could proceed, however, Talbot stood up and declared that there was a traitor among them. He then turned on Coulson and revealed that his team had infiltrated the symposium. Malick joined the room and revealed Coulson's name, calling him the Director of HYDRA. Malick then showed images of Lash's victims to convince the attendees that Coulson was working for the extermination of the Inhumans. Coulson was removed from the talks to be imprisoned.
Later, Malick met with Petrov and supported his idea of creating an Inhuman Sanctuary, offering his assistance on the matter.
Phil Coulson was locked up in the basement of the Symposium's building as well as General Glenn Talbot, who was betrayed by Gideon Malick. After explaining that he was building an army of Inhumans, Malick ordered his men to kill Coulson and Talbot before leaving, but Carl Creel prevented the HYDRA operatives to kill them and released Coulson and Talbot.
Anton Petrov returned to Russia and, with the support of Malick, he continued designing the Russian Inhuman Sanctuary, which would later be infiltrated by S.H.I.E.L.D. Agents Lance Hunter and Bobbi Morse. The project was eventually aborted.