Holden Radcliffe was exposed to the corrupting influence of the infamous grimoire known as the Darkhold. As a result, Radcliffe became obsessed with the idea of reclaiming the book for himself and achieving his dreams of immortality. To that end, Radcliffe reprogrammed the Life-Model Decoy Aida he had built earlier with a protocol hidden in Aida's information cache and deemed Sunset Protocol.
Radcliffe seized the opportunity to activate the Sunset Protocol as Melinda May was instructed by S.H.I.E.L.D. Director Jeffrey Mace to enlist Aida's assistance for the Battle at the Chinatown Crew Headquarters and then destroy the Darkhold. As May left the Playground, Radcliffe called Aida and told her to locate and activate the Sunset Protocol.
Aida welcomed May at the Radcliffe Residence and took her to the lab, pretending she needed to retrieve some equipment. Once in the lab, Aida attacked May and drugged her before replacing May by a LMD.