St. Louis is the second largest city of the state of Missouri.
S.H.I.E.L.D. Agent Piper, who had lost track of her fellow agents in the aftermath of the last battle against Aida, struck a deal with General Hale and planted the Kree Orb in the St. Louis Aerospace Facility, periodically activating it and hoping that her former colleagues would notice it.
The light beams emitted in the city of St. Louis were spotted by the Chronicom Noah from the Lighthouse. Noah informed the S.H.I.E.L.D. agents, who had just returned from the future, and they decided to go to St. Louis in order to investigate. The team infiltrated the facility and reunited with Piper before starting to study the Kree Orb.
However, as they realized that Piper had betrayed them by siding with Hale, a group of Sleeper Mechs led by Ruby Hale arrived in the facility to ambush the S.H.I.E.L.D. team. A fierce battle erupted between the agents and the androids. In the end, although Yo-Yo Rodriguez had her arms cut off by Ruby, the S.H.I.E.L.D. team managed to retreat to the Zephyr One and hastily left St. Louis.