Seymour O'Reilly is an alumnus at the Midtown School of Science and Technology.
O'Reilly attended classes at the Midtown School of Science and Technology where he was good friends with Liz Toomes and her little group of friends. During his physical education class, he and his friends discussed about the Avengers. When Toomes mentioned her interest in Spider-Man, O'Reilly asked her whether she would still like him if he happened to be seriously burned, to which Toomes replied that she would. O'Reilly was then utterly surprised when Ned Leeds announced that Peter Parker knew Spider-Man.
- Midtown School of Science and Technology
- Monica Warren - Former Teacher
- Roger Harrington - Former Teacher
- Liz Toomes - Former Classmate and Decathlon Leader
- Ned Leeds - Former Classmate
- Peter Parker - Former Classmate
- Michelle Jones - Former Classmate and Decathlon Leader
- Flash Thompson - Former Classmate
- Sally Avril - Former Classmate
- Cindy Moon - Former Classmate
- Abe Brown - Former Classmate
- Betty Brant - Former Classmate
- Tiny McKeever - Former Classmate
- Charles Murphy - Former Classmate
- Jason Ionello - Former Classmate
- In the comics, Seymour O'Reilly was part of Flash Thompson's gang and would pick on Peter Parker. He was usually a suck-up to Flash and was apparently immature, as even after graduation he never gave up his bullying ways. Seymour attended his high school reunion with Peter, only to become envious of his marriage to Mary Jane Watson. He found out that Peter was Spider-Man, but was immediately killed by Venom.