One month after the Attack on the IFID Headquarters, Peter Parker was preparing to leave his home as May Parker sees the news about the Bombing of the Vienna International Centre. Parker sees his aunt May worried and tells her to relax.
Upon returning home from school, Peter Parker spotted a strange car parked outside and asked May Parker about it before seeing Tony Stark talking with May. Parker became confused when Stark told May that Stark Industries planned to give him a sizable grant, claiming that Parker had signed up for it in the past. Stark then privately talked to Parker in his room, showing him footage of him, wearing Spider-Man Suit and stopping a car crash.
Parker claimed that the video was just a fake and denied being Spider-Man, however, Stark found his suit and blew his cover. Parker had no choice but to confess that he is Spider-Man, so Stark invited him to come to Germany to confront Captain America. He then decided to tell May about Parker's "field trip", however, he used his Web-Shooters to bind Stark's hand to the doorknob, pleading with him to keep the truth from May.
As the Clash of the Avengers was ended, Parker was brought home by Stark and Happy Hogan and Stark even allowed him to keep the suit he created. May gave Parker an ice bag for his black eye which he had gained when Captain America had struck him hard across the face during the battle. When May asked Parker who had injured him, he told her about a Brooklyn man named "Steve" and his huge friend. When May had exited the room, Parker continued to inspect his new Web-Shooters and discovered Spider-Signal, as well as other upgrades implemented by Stark. Within the next two months, May and Parker relocated to a new apartment.
Found by Ned Leeds
Following the Robbery at Queens Community Bank, Spider-Man had returned back to the Parker Residence where he was witnessed by Ned Leeds. Parker desperately attempted to insist that he was not the Spider-Man, although Leeds had clearly figured it all out already. Parker then took off the suit and tried to convince Leeds that he got it all wrong, but they were interrupted by May Parker. May told Parker that would be eating at the restaurant and invited Leeds, however, Parker insisted that Leeds could not stay.
Following some more arguing, Parker had finally convinced Leeds to keep it a secret from May, not wanting to cause any more distress onto his aunt, which Leeds reluctantly agreed to before leaving while still asking Parker questions about being Spider-Man.
Search for Vulture
Returned back home, Peter Parker resumed his hunt for Vulture as he spoke with Karen. Parker asked if Karen could help him identify the criminals he encountered under the bridge, as she revealed that she had access to the footage through the Baby Monitor Protocol. Parker then watched the footage, seeing Jackson Brice and Herman Schultz as they threatened Aaron Davis before Spider-Man had stepped in.
Losing Spider-Man Suit
Getting home, Peter Parker found May Parker frustrated and worried for him, as she explained how she had been calling everywhere for Parker's whereabouts. Noting how she knew he left the hotel room in Washington, D.C. and snuck out their home each night, May demanded answers. Parker explained that he had lost the Stark Industries' internship, claiming that he had managed to screw everything up. May believed his story and simply comforted Parker, while he apologized for getting her so worried about him.
As Liz Toomes agreed to go dancing with him, Peter Parker hurriedly returned home and immediately asked May Parker for her assistance to get ready for the homecoming dance. May helped him with clothes and also assisted Parker in learning how to dance. Parker also wrapped up a flower corsage which he had intended to give to Toomes as a gift.
Once Parker returned back home, he discovered that Tony Stark had returned his second Spider-Man Suit. Excited Parker put on the suit again, however, May Parker saw him putting on the suit, watching in Parker's doorway as he had pulled off his mask and then loudly cursing as she questioned what was going on, much to Parker's utter shock and horror.
In 2018, May Parker was at home in her apartment when Thanos' Snap occurred. As Peter Parker had died as well, the apartment was vacant and was eventually rented to another family. Five years later, the effects the Snap were undone, causing May to reappear in her old apartment. However, her appearance shocked its current occupants, with the grandmother of the new family believing she was a ghost while the wife thought her to be a mistress. May was soon reunited with her nephew and the duo moved into another apartment as a result.
Prior to a summer trip to Europe, Peter Parker went home to pack his stuff, choosing to leave his Spider-Man Suit behind so he could enjoy his field trip without having to worry about responsibilities. However, May Parker later packed his suit herself without his knowledge.
Returning to New York City, Parker met with May and Happy Hogan, asking them about their relationships. May and Hogan both awkwardly replied to Parker's questions, and while Hogan was confident about their relationships, May was not so sure. Parker then interrupted then and left home for his date with Michelle Jones.
- According to May Parker in Spider-Man: Homecoming, their second apartment was located six blocks away from Delmar's Deli-Grocery shop. When Ned Leeds and Peter Parker were walking to school, Delmar's is seen to be situated on the corner of 21st Street, placing their apartment on 15th Street.