The Omnicrafts are remotely controlled spacecrafts used by the Sovereign to hunt down their enemies across space.
Having discovered that the Guardians of the Galaxy had stolen Anulax Batteries from the Sovereign, the High Priestess Ayesha sent a fleet of Omnicrafts after the Milano to chase them. As several ships were destroyed, Ayesha ordered the Admiral to have the pilots shoot with intent to kill, despite the risk of causing the Anulax Batteries to explode.
However, despite managing to hit the Milano, many spacecrafts were destroyed when crossing a Quantum Asteroid Field. The only remaining Omnicraft through the asteroid field, piloted by Zylak, was then destroyed by Drax the Destroyer. Then another fleet which had gone around the asteroid field nearly destroyed the Milano, but it was completely obliterated by Ego.
Despite this major defeat, another fleet led by Ayesha in person was soon prepared as the Sovereign were not willing to give up on their target. They tracked down the stolen batteries on Ego's Planet, and found the Guardians of the Galaxy in the depths of it as they attempted to pierce through its core with the Laser Drill.
The fleet was able to deal significant damage to the drill, causing the thrusters to stop and thus immobilizing the ship. However, Yondu Udonta and Nebula managed to restore power to the laser drill, using the lasers to once again completely annihilate the fleet much to Ayesha's outrage. Ironically, the Anulax Batteries the Sovereign were looking for were destroyed shortly afterwards in the explosion meant to kill Ego.
Ayesha later feared that she would be blamed by the Sovereign council for the loss of all those valuable spacecrafts, but remained confident that the creation of Adam Warlock would be more than enough to compensate for the destroyed Omnicrafts.