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Natalia Cordova-Buckley portrayed Yo-Yo Rodriguez in Agents of S.H.I.E.L.D.. She portrayed an alternate version of the character in the episodes The Last Day and Past Life.

She was a recurring guest star in Season Three and Season Four, and was upgraded to a starring cast member in Season Five.

She also portrayed the character in Agents of S.H.I.E.L.D.: Slingshot.

She also portrayed Izel in possession of Yo-Yo Rodriguez's body in the Agents of S.H.I.E.L.D. episodes Leap, From the Ashes and The Sign.

She portrayed herself in Agents of S.H.I.E.L.D.: Academy.

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