- He was nominated for a Saturn Award for Best Supporting Actor in a Film for his work on Spider-Man: Homecoming.
- Michael Keaton's real name is Michael Douglas but uses a stage name (named for his affinity for comedic actor Buster Keaton) due to there being another well-known actor with the same name.
- Tom Holland revealed in an interview with ShortList that Michael Keaton would amuse him on the set of Spider-Man: Homecoming by quoting Batman.
- Michael Keaton previously worked with Robert Downey, Jr. in Game 6.
- Michael Keaton previously worked with Marisa Tomei in The Paper.
- Michael Keaton previously worked with J.B. Smoove in Clear History.
- Michael Keaton previously worked with Samuel L. Jackson in Jackie Brown, Out of Sight, The Other Guys and RoboCop.
- Michael Keaton is one of the actors to portray characters for both Marvel Studios and DC Entertainment. He portrayed Bruce Wayne/Batman in Batman and Batman Returns.
- Michael Keaton previously dated Michelle Pfeiffer.