- He won a BET Award for Best Actor for his work on Luke Cage.
- He won a Black Reel Award for Outstanding Guest Performer, Drama Series for his work on Luke Cage.
- Mahershala Ali is one of the actors who have portrayed multiple characters in the Marvel Cinematic Universe.
- Mahershala Ali's role as Cottonmouth in the first season of Luke Cage gave him the inspiration and the idea to be cast as Blade, and contacted his agent on the day Luke Cage premiered to inquire about Marvel Studios' plans for the franchise.
- Mahershala Ali creates mixtapes for each character he portrays, and Cottonmouth's mixtape includes songs from Big L, Diamond D, Brand Nubian, D'Angelo, Mobb Deep, Kanye West and Erykah Badu.
- Mahershala Ali also voiced Aaron Davis/Prowler in the Sony Pictures Studios production Spider-Man: Into the Spider-Verse.
- Mahershala Ali previously worked with Brian Tyree Henry in Spider-Man: Into the Spider-Verse.
- Mahershala Ali shares his birthday with Elizabeth Olsen and Christopher Eccleston.