While Dave and Kurt celebrated their distraction of the police, they accidentally pressed their van's "La Cucaracha" horn, which Jim Paxton recognized. While they attempted to hide so Kurt could finish his hack, they were soon pulled from the van and were nearly handcuffed. They managed to escape when explosions and gunfire were heard which distracted the police, allowing Dave and Kurt to pick up Luis and escape.
When they heard that Scott Lang was fighting Darren Cross at his ex-wife's home and his young daughter Cassie Lang was now in danger, Dave drove the team to the location, intending to help as best they could. When they arrived, however, they discovered the house was surrounded by police; not wishing to be arrested, Dave drove the car backwards and made an awkward retreat.
Luis' van was later used to help smuggle the van Dyne family, including a successfully rescued Janet van Dyne, to safety.
Months later, the back of Luis' van was used to house a Quantum Tunnel, which Lang used to travel to the Quantum Realm to collect quantum energy to cure Ghost. But before the Pym family could pull him back, they were killed off by Thanos' Snap, leaving Lang trapped in the Quantum Realm and Luis' van unattended.
"Time travel test number one. Scott, fire up the, uhh... The van thing."
With no one to claim the van, the city authorities retrieved it and placed it in a storage warehouse. Five years later, a rat accidentally activated the control panel, freeing Scott Lang from the Quantum Realm. After Lang discovered how long he'd been away and what had happened, he pulled the van out of storage and drove to the New Avengers Facility to meet Captain America and Black Widow where he revealed his plan to use the Quantum Tunnel as a time machine so they could find past versions of the Infinity Stones and use them to undo Thanos' work. After Bruce Banner had been recruited, the quartet tried to use the van to time travel but, rather than pushing Lang through time, they wound up pushing time through Lang, causing him to shift through various ages. When Tony Stark was convinced to join them, the van was abandoned as he and Rocket Raccoon built a new, more advanced Quantum Tunnel.
While the Time Heist, as it came to be known, was successful in enacting the Blip, a past version of Thanos from an altered 2014 had become aware of the Avengers' plan and had followed them to 2023, where he used the Sanctuary II to destroy the compound. Though the van survived the bombardment, it was left totaled, winding up on Thanos' side of the line in the Battle of Earth. Shrinking down past the alien army, Lang and a resurrected Hope managed to enter the van and jump start the time portal. After securing the Nano Gauntlet, Captain Marvel flew for the van so she could return the Stones only for Thanos to throw his sword at the van, causing the tunnel within to explode, destroying the van.