Loki took his knives when he went to Jotunheim with Thor as he intended to attack the Frost Giants. During the ensuing fight, Loki threw a dagger at one of a Frost Giant, instantly killing him. He then stabbed another enemy with a knife, but this enabled the Frost Giant to grab his arm, causing Loki to begin to understand his true nature as a Frost Giant himself as he was unaffected by this.
Loki used a small knife during his duel against Thor in the Battle of New York, stabbing his adoptive brother while pretending to be sensitive to his request that Loki should stop the Chitauri army. The blade, however, was far too small and thin to seriously injure Thor, who removed it from his body without suffering from significant pain.
Loki was given a dagger by Thor after he was released from the Asgardian Dungeons, despite Thor's reluctance to entrust his brother with a weapon. As they prepared to confront Malekith on Svartalfheim, Loki feigned to betray Thor and to stab him with the knife, later creating an illusion as if Loki amputated Thor of his hand and forearm. Loki later used his dagger to take down an entire group of Dark Elves in the ensuing confrontation and failed attempt to reclaim the Aether.
Loki threatened Doctor Strange with a pair of daggers after he was released from a dimension of void in which he had been falling for thrity minutes while Doctor Strange met with Thor. However, Loki was forcibly transported to Norway before he could attack Doctor Strange.
Upon meeting Hela and witnessing her considerable powers, Loki attempted to flee back to Asgard. However, Hela followed them into the Bifrost Bridge, prompting Loki to throw a dagger at her in an attempt to stop her. Hela caught the knife and promptly threw it back at Loki, causing him to be ejected from the Bifrost, eventually landing on Sakaar.
Loki used a pair of dual blades against Valkyrie as they had both been tasked by the Grandmaster with finding Thor. Using his weapons, Loki was able to block Valkyrie's arm, thus revealing her tattoo signaling her former allegiance, and even managed to disarm her. However, this was not enough to prevent Valkyrie from overpowering him in the end.
Confronting Thanos and the Black Order who had slaughtered half of the population of the Statesman, Loki approached the Mad Titan, pretending to be ready to join him. He then stealthily took a knife and concealed it in his hand before trying to stab Thanos in the throat. However, Thanos saw through Loki's scheme and blocked the strike using the Infinity Gauntlet, disarming Loki and eventually killing him by choking him to death.