Hundreds of years ago, the Tivan Group set up mining operations in the decapitated head of the Celestial avatar, in order to harvest the valuable bone, brain tissue, and spinal fluid from it. The absence of rules and regulations turned Knowhere into a safe haven for outlaws.
Securing the Aether
Asgardians Sif and Volstagg arrived at the Collector's Museum inside Knowhere to deliver the Aether to the Collector. They were introduced to the infamous Taneleer Tivan by Carina, and willingly gave the Aether to him, not realizing that he was apparently seeking the other Infinity Stones.
In 2014, the Guardians of the Galaxy arrived at Knowhere with the intention of selling the Orb to Tivan. After he explained that the Orb was a containment device for one of the Infinity Stones, his assistant Carina attempted to free herself from his servitude by using the Orb, but she and the Collector's Museum were destroyed, releasing Cosmo and Howard the Duck in the process.
Meanwhile, Drax the Destroyer, obsessed with avenging the deaths of his wife and daughter, alerted Ronan the Accuser to their presence. Ronan's forces attacked Knowhere while he and Drax faced each other in hand-to-hand combat. Easily overpowering Drax and leaving him to die, Ronan took possession of the Orb. Sometime following the Battle of Xandar, Taneleer Tivan sat at the remains of his museum, getting licked by Cosmo and having a drink with Howard the Duck.
- "We need to stop Thanos! Which means, we mean to find out where he's going next."
"He must be going somewhere."
"No, no. Knowhere? It's a place, we've been there. It sucks. Excuse me, that's our food."
"Thor, why would he go to Knowhere?"
"Because for years, the Reality Stone's been safely stored by a man named the Collector."
"If it's with the Collector, then it's not safe. Only an idiot would give that man a stone."
- ―Gamora, Thor, Mantis and Star-Lord
- In the comics, Knull decapitated a Celestial's head and as it eroded over a millennia; it was taken placed as a city known as Knowhere.