Karen Page tricked Ben Urich into visiting Marlene Vistain, Wilson Fisk's mother, at Saint Bénézet Retirement Care. In a rare moment of clarity, Vistain called Fisk to tell him about the visitors. Fisk, tending to the ill Vanessa Marianna, asked James Wesley to return her call. When Wesley heard Vistain talk about the pretty blonde with the big blue eyes who came asking questions about her son, he realized it was likely Page.
- "But you won't be the first to die, Miss Page. No, I think Mr. Urich will have that honor. Then we'll go to your place of employment, see to Mr. Nelson, Mr. Murdock. After that your friends, family, everyone you've ever cared about. And when you have no tears left to shed then, then we'll come for you, Miss Page."
- ―James Wesley to Karen Page
James Wesley drugged Karen Page as she was returning to her apartment building one evening, and brought her to an empty warehouse. She was still having trouble moving as the effects of the drug slowly wore off. He told her that he knew she had visited Marlene Vistain, and lamented that Wilson Fisk had not ordered her to be killed after she uncovered the scandal at Union Allied Construction. He then pulled out a gun and placed in on the table in front of him.
He offered her a job; he wanted her to tell Ben Urich and everyone else who was digging up information about Fisk that she had been wrong about him, and that he was really a good man trying to save Hell's Kitchen. She replied that she'd rather die first. Wesley responded by saying she wouldn't be the first to die. He told her Urich would die first, followed by Foggy Nelson and Matt Murdock, and anyone else she ever cared about, and only after they were all dead would she be killed.
Wesley's phone rang, and when he went to answer it, Page grabbed the gun and pointed it at him. He ignored the phone and jokingly asked if she thought he'd really leave a loaded gun on the table. She cocked the gun and asked him if he thought she'd never fire a gun before. He began to stand up, and Page fired seven rounds at him, killing him.
- "James Wesley. What was it like for you when he disappeared? Really, it's those first 24 hours that are the worst, aren't they? When you call and you call and you call, and there's just no answer. It becomes an obsession. The calling. The never-ending loop of a ghost's voice mail in your ear. You worry. You wonder. You swear, "God damn it, if he's still living, I'm gonna kill him myself." Is that what it was like for you? Did you rage at him? 'Cause you thought he betrayed you? Because I wonder what would be worse for you. His duplicity or his death? He died quickly. If you were wondering. Didn't suffer much. You see, Wilson, Matt Murdock isn't the person you should be worried about. I killed Wesley. I shot him seven times. Because the clip ran out. He deserved more."
- ―Karen Page to Wilson Fisk
Wilson Fisk was concerned when he could not locate James Wesley. Karen Page wiped her prints from the crime scene, discarded the gun, returned to her apartment and drank herself to sleep to deal with the stress of having killed Wesley.
Page pushed Ben Urich to write an article based on what they learned from Marlene Vistain, telling him she believed Fisk knew about their visit, although she would not explain why she felt this way.