- He was nominated for an MTV Movie Award for Best Villain for his work on Avengers: Age of Ultron.
- He was nominated for an MTV Movie Award for Best Virtual Performance for his work on Avengers: Age of Ultron.
- James Spader was initially approached by the crew of Avengers: Damage Control to reprise his role as Ultron. However, Spader was unavailable due scheduling conflicts, leading Ultron to be recast with Ross Marquand.
- James Spader previously worked with Robert Downey, Jr. in Tuff Turf and Less Than Zero.
- James Spader previously worked with Josh Brolin in Slow Burn.
- James Spader shares his birthday with Deborah Ann Woll.
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