The Hong Kong Sanctum was the last Sanctum to be attacked by the Zealots in their crusade against the Masters of the Mystic Arts to unleash the Dark Dimension on Earth. Wong led a team of Masters of the Mystic Arts to defend the Sanctum against Kaecilius and his followers, but they were ultimately defeated, leading to the fall of the Hong Kong Sanctum, which was destroyed while the Dark Dimension invaded Earth.
However, the battle took a new turn as Doctor Strange and Karl Mordo joined the fight. Using the powers of the Eye of Agamotto, Strange successfully reverted time, which in turn led to the rebuilding of the Sanctum. The process was still when Kaecilius and the Zealots broke free of the spell, thus resuming the fight. Nonetheless, Strange ultimately managed to have Dormammu to call the Zealots in the Dark Dimension and to leave Earth, which enabled the Sanctum to stand and be restored under the rule of Tina Minoru.
- "Sanctum Sanctorum" is a Latin translation of the biblical term "Holy of Holies".