Herefordshire is a county located in the west of England.
HYDRA had a research facility located in Herefordshire, where Daniel Whitehall and Wolfgang von Strucker oversaw the advancement of the Project Destroyer of Worlds. The facility was left abandoned in the aftermath of the Destruction of HYDRA.
Having identified the HYDRA Herefordshire Facility as a possible location for a HYDRA weapon Hale was looking for, a S.H.I.E.L.D. team comprised of Jemma Simmons, Leo Fitz and Yo-Yo Rodriguez flew a Quinjet to Herefordshire in order to infiltrate the facility.
The S.H.I.E.L.D. team managed to break into the facility, where they discovered that it was overrun by Sleeper Mechs led by Anton Ivanov. Nevertheless, the S.H.I.E.L.D. agents managed to sneak into the facility and found the Particle Infusion Chamber, but they were soon confronted by the androids. Although Fitz and Simmons managed to hold their own against the Sleeper Mechs and Rodriguez successfully killed Ivanov, Fitz and Simmons were confronted by Ruby Hale and Werner von Strucker, who had journeyed to Herefordshire as well.
While Fitz and Simmons were forced to repair the Particle Infusion Chamber they had damaged and watched as Ruby painfully underwent the Gravitonium infusion process, S.H.I.E.L.D. agents Quake and Melinda May arrived in Herefordshire, accompanied by Hale. Although they attempted to calm Ruby down after her infusion, Ruby was eventually murdered by Rodriguez. Upon Ruby's death, her body unleashed a powerful blast which knocked everyone out. When they regained consciousness, the S.H.I.E.L.D. agents discovered that Hale had fled and they eventually left Herefordshire as well.