Marvel Cinematic Universe Wiki

The recent release of the book "Marvel Studios' The Marvel Cinematic Universe: An Official Timeline" requires a lot of analysis. Members of WikiProject:Timeline team are working on editing pages in response to the information revealed in the book. If you wish to contribute, please do not immediately edit these pages, and instead visit the Timeline Discussion.

READ MORE

Marvel Cinematic Universe Wiki
Register
Marvel Cinematic Universe Wiki
Tag: Visual edit
No edit summary
(42 intermediate revisions by 18 users not shown)
Line 1: Line 1:
 
{{Item
 
{{Item
 
|image = GH.325.png
 
|image = GH.325.png
|creator = [[Project T.A.H.I.T.I.]]
+
|creator = [[Project T.A.H.I.T.I.]] <small>(original)</small><br>[[Raina]] <small>(distilled variant)</small>
 
|users = [[Phil Coulson]]<br>[[Daisy Johnson]]<br>[[John Garrett]]<br>[[Rebecca Stevens]]<br>[[Lewis Seaver]] †<br>[[Hank Thompson|Cameron Klein]]<br>[[T.A.H.I.T.I. Patient 4]]<br>[[T.A.H.I.T.I. Patient 5]]<br>[[Sebastian Derik]]
|made =
 
 
|tv series = ''[[Agents of S.H.I.E.L.D.]]''
|owners =
 
 
|status = In Use}}
|users = [[Phil Coulson]]<br>[[Skye]]<br>[[John Garrett]]<br>[[Rebecca Stevens]]<br>[[Lewis Seaver]]<br>[[Cameron Klein]]<br>[[T.A.H.I.T.I. Patient 4]]<br>[[T.A.H.I.T.I. Patient 5]]<br>[[Sebastian Derik]]
 
  +
{{Quote|The drug that healed [[Skye]] and brought [[Phil Coulson|Coulson]] [[Resurrection of Phil Coulson|back to life]].|[[Raina]]|Ragtag}}
|tv = ''[[Agents of S.H.I.E.L.D.]]''
 
 
'''GH.325''' is one of a number of drugs derived from the blood of a [[Kree]] corpse code named "[[G.H.]]". When administered, the drug causes rapid healing by promoting advanced cellular regeneration, healing severe and fatal wounds, and in some cases can even revive the recently deceased.
|status = Unknown}}
 
{{Quote|No, don't give it to [[Skye|her]]. The drug... they can't give it to her!|[[Phil Coulson]]|T.A.H.I.T.I.}}
 
'''GH.325''' is one of a number of drugs derived from the bodily fluid of a [[Kree]] corpse code named "[[G.H.]]". When administered, the drug causes rapid healing by promoting advanced cellular regeneration, healing severe and fatal wounds, and in some cases can even revive the recently deceased.
 
   
 
==History==
 
==History==
  +
===Origins===
{{Quote|I believe [[John Garrett|Garrett]] and I had a negative reaction to the [[G.H.|alien]] DNA in our system. Maybe [[Skye|you]] didn't because it was already there.|[[Phil Coulson]]|A Hen in the Wolf House}}
+
{{Quote|I believe [[John Garrett|Garrett]] and I had a negative reaction to the [[Kree|alien]] DNA in our system. Maybe you didn't because it was already there.|[[Phil Coulson]] to [[Skye]]|A Hen in the Wolf House}}
 
In the closing days of [[World War II]], the [[Strategic Scientific Reserve]] conducted a raid on one of the final active [[HYDRA]] bases, a secure [[HYDRA Research Facility Number 4|research facility]]. After taking control of the base, the Strategic Scientific Reserve took custody of all assets and artifacts within the base, among which was the corpse of a [[Kree]], which had been part of an attempted invasion force that visited Earth thousands of years ago and was left behind.<ref>''[[Shadows|Agents of S.H.I.E.L.D.: 2.01: Shadows]]''</ref>
   
 
The corpse, given the designation "[[G.H.]]", was transferred to a facility known as the [[Guest House]] where it was [[Project T.A.H.I.T.I.|studied intensively]]. From the G.H.'s bodily fluids, scientists were able to synthesize a number of advanced drugs with varying effects on human biology, including the serum GH.325, a serum with the potential to revive the recently deceased.<ref name="AoS114">''[[T.A.H.I.T.I.|Agents of S.H.I.E.L.D.: 1.14: T.A.H.I.T.I.]]''</ref>
In the closing days of [[World War II]], the [[Strategic Scientific Reserve]] conducted a raid on one of the final active [[HYDRA]] bases, a secure [[HYDRA Storage Facility|storage depot]]. After taking control of the base, the Strategic Scientific Reserve took custody of all assets and artifacts within the base, among which was the corpse of a [[Kree]], which had been part of an attempted invasion force that visited Earth thousands of years ago and was left behind.<ref>''[[Shadows|Agents of S.H.I.E.L.D.: 2.01: Shadows]]''</ref>
 
 
The corpse, given the designation "[[G.H.]]", was transferred to a facility known as the [[Guest House]] where it was [[Project T.A.H.I.T.I.|studied intensively]]. From the G.H.'s bodily fluids, scientists were able to synthesize a number of advanced drugs with varying effects on human biology, including the serum GH.325, a serum with the power to revive the recently deceased.<ref name="AoS114">''[[T.A.H.I.T.I.|Agents of S.H.I.E.L.D.: 1.14: T.A.H.I.T.I.]]''</ref>
 
   
  +
===Project T.A.H.I.T.I.===
  +
{{Quote|We need to shut down the program."<br>"This isn't a failure, Agent Coulson. It's a first step. We rejuvenated life.|[[Phil Coulson]] and [[Goodman]]|The Writing on the Wall}}
 
Under [[Project T.A.H.I.T.I.]], the drug was intended to be used to heal an [[Avengers|Avenger]] should one become seriously wounded or die in the line of duty.<ref name="AoS120">''[[Nothing Personal|Agents of S.H.I.E.L.D.: 1.20: Nothing Personal]]''</ref>
 
Under [[Project T.A.H.I.T.I.]], the drug was intended to be used to heal an [[Avengers|Avenger]] should one become seriously wounded or die in the line of duty.<ref name="AoS120">''[[Nothing Personal|Agents of S.H.I.E.L.D.: 1.20: Nothing Personal]]''</ref>
   
Line 23: Line 23:
 
Having witnessed the psychological breakdown of all of the test participants and the unethical methods used to heal them, Coulson made a final report in which he appealed to S.H.I.E.L.D.'s director, [[Nick Fury]], to have Project T.A.H.I.T.I. terminated due namely to the horrific side effects of the GH.325 serum and its related procedures, while also resigning from his position as supervisor.<ref name="AoS120"/>
 
Having witnessed the psychological breakdown of all of the test participants and the unethical methods used to heal them, Coulson made a final report in which he appealed to S.H.I.E.L.D.'s director, [[Nick Fury]], to have Project T.A.H.I.T.I. terminated due namely to the horrific side effects of the GH.325 serum and its related procedures, while also resigning from his position as supervisor.<ref name="AoS120"/>
   
  +
===Resurrections and Secrets===
When Agent Coulson himself was fatally stabbed through the heart by the rogue [[Asgardians|Asgardian]], [[Loki]], S.H.I.E.L.D. director Fury used his connections to allow Coulson to undergo a series of intensive surgeries at the Guest House that brought him [[Resurrection of Phil Coulson|back to life]] after being dead for several days. Among the processes used on Coulson was the administering of the GH.325 serum, which had the effect of completely regenerating his eviscerated heart tissue. However, the use of this serum, along with all other details of his resurrection, was kept secret from Coulson after his memories of the operation were erased.<ref>''[[The Magical Place|Agents of S.H.I.E.L.D.: 1.11: The Magical Place]]''</ref>
 
  +
{{Quote|In the history of bad ideas, [[Memory Overwriting Machine|this]] is light years ahead of everything."<br>"No, trying to bring dead agents back to life using [[Kree|alien]] blood blows everything else away.|[[Skye]] and [[Phil Coulson]]|The Writing on the Wall}}
 
 
When Agent [[Phil Coulson]] himself was fatally stabbed through the heart by the rogue [[Asgardians|Asgardian]], [[Loki]], [[S.H.I.E.L.D.]] Director [[Nick Fury]] used his connections to allow Coulson to undergo a series of intensive surgeries at the Guest House that brought him [[Resurrection of Phil Coulson|back to life]] after being dead for several days. Among the processes used on Coulson was the administering of the GH.325 serum, which had the effect of completely regenerating his eviscerated heart tissue. However, the use of this serum, along with all other details of his resurrection, was kept secret from Coulson after his memories of the operation were erased.<ref>''[[The Magical Place|Agents of S.H.I.E.L.D.: 1.11: The Magical Place]]''</ref>
Later, during a mission carried out by Agent Coulson's [[Coulson's Team|personal team]], [[Skye]], an inexperienced asset recruited by Coulson, was shot twice in the abdomen and left for dead. This event deeply affected Coulson, who felt personally responsible, motivating him to research all aspects of his mysterious resurrection in order to find something capable of saving Skye's life. His search led him and a small team to execute an unwilling raid on the Guest House in search of the drug. While the GH.325 was successful in restoring Skye's health, the raid resulted in the destruction of the [[Guest House]], burying all existing stock of the drugs, along with its source,<ref name="AoS114"/> excluding a few vials, labelled GH but with different numbers, retrieved by [[John Garrett]] in secret.<ref>''[[Providence (episode)|Agents of S.H.I.E.L.D.: 1.18: Providence]]''</ref>
 
 
[[File:GH_Cables.png|thumb|300px|Body fluids being harvested from [[G.H.]] to create GH.325.]]
 
   
 
Later, during a mission carried out by Agent Coulson's [[Coulson's Team|personal team]], [[Skye]], an inexperienced asset recruited by Coulson, was shot twice in the abdomen and left for dead. This event deeply affected Coulson, who felt personally responsible, motivating him to research all aspects of his mysterious resurrection in order to find something capable of saving Skye's life. His search led him and a small team to execute an unwilling raid on the Guest House in search of the drug. While the GH.325 was successful in restoring Skye's health, the raid resulted in the destruction of the [[Guest House]], burying all existing stock of the drugs, along with its source,<ref name="AoS114"/> excluding a few vials, containing other GH formulas, which were retrieved by [[John Garrett]] in secret.<ref name="AoS118">''[[Providence (episode)|Agents of S.H.I.E.L.D.: 1.18: Providence]]''</ref>
 
[[File:GH_Cables.png|thumb|250px|left|Body fluids being harvested from [[G.H.]] to create GH.325]]
 
Upon learning of the miracle drug's true source, Agent Coulson became extremely apprehensive of its use and possible side effects on himself and Skye. At his behest, Coulson had his team member and S.H.I.E.L.D. scientist [[Jemma Simmons]] actively monitor the serum's effects on Skye. Personally interested in how the GH.325 could benefit humanity, Simmons hoped to recreate the drug by repeatedly analyzing Skye's blood. However, she was unable to discover anything unusual in the blood samples, even when comparing them to Coulson's blood. When she asked Coulson to send blood samples to their [[S.H.I.E.L.D. Headquarters|Headquarters]] in order to analyze them and mend her lack of available resource, Coulson denied permission without explaining to Simmons the real reason for doing so.<ref name="AoS115">''[[Yes Men|Agents of S.H.I.E.L.D.: 1.15: Yes Men]]''</ref>
 
Upon learning of the miracle drug's true source, Agent Coulson became extremely apprehensive of its use and possible side effects on himself and Skye. At his behest, Coulson had his team member and S.H.I.E.L.D. scientist [[Jemma Simmons]] actively monitor the serum's effects on Skye. Personally interested in how the GH.325 could benefit humanity, Simmons hoped to recreate the drug by repeatedly analyzing Skye's blood. However, she was unable to discover anything unusual in the blood samples, even when comparing them to Coulson's blood. When she asked Coulson to send blood samples to their [[S.H.I.E.L.D. Headquarters|Headquarters]] in order to analyze them and mend her lack of available resource, Coulson denied permission without explaining to Simmons the real reason for doing so.<ref name="AoS115">''[[Yes Men|Agents of S.H.I.E.L.D.: 1.15: Yes Men]]''</ref>
   
Agent Simmons continued to research and analyze the drug in secret, eventually gaining access to a better lab at the [[Hub (S.H.I.E.L.D. Facility)|Hub]] and receiving help from Agent [[Antoine Triplett]], who used his higher [[Clearance Level]] to help contact Agent [[Anne Weaver]] for Simmons to consult on her analysis. Unfortunately, before much progress could be made, Simmons was interrupted by the [[S.H.I.E.L.D. Civil War|Assault on S.H.I.E.L.D.]] by [[HYDRA]] sleeper agents.<ref>''[[Turn, Turn, Turn|Agents of S.H.I.E.L.D.: 1.17: Turn, Turn, Turn]]''</ref>
+
Agent Simmons continued to research and analyze the drug in secret, eventually gaining access to a better lab at the [[Hub (S.H.I.E.L.D. Facility)|Hub]]. Unfortunately, before much progress could be made, Simmons was interrupted by the [[HYDRA Uprising|Assault on S.H.I.E.L.D.]] by [[HYDRA]] sleeper agents.<ref>''[[Turn, Turn, Turn|Agents of S.H.I.E.L.D.: 1.17: Turn, Turn, Turn]]''</ref> Following the assault, [[Grant Ward]] passed on an encrypted hard drive containing all of Simmons' GH.325 research to his [[HYDRA]] superior [[John Garrett]].<ref name="AoS118"/>
   
  +
===Re-created===
After accessing [[Coulson's Team Hard Drive]] and researching Coulson's and Skye's blood samples, [[Raina]] was able to duplicate something she believed was similar to GH.325, though she would not guarantee its results. She ultimately used this on the fatally injured [[John Garrett]] after his cybernetic implants were destroyed by an EMP activated by [[Leo Fitz]].<ref>''[[Ragtag|Agents of S.H.I.E.L.D.: 1.21: Ragtag]]''</ref>
 
  +
{{Quote|You've re-created GH-325."<br>"Almost. We've distilled the genetic components of all the previous samples down to one single vial."<br>"And it'll do what we talked about?"<br>"It should regenerate and heal cells, just like it did in [[Skye]] and [[Phil Coulson|Coulson]].|[[Grant Ward]], [[Raina]], and [[John Garrett]]|Ragtag}}
 
[[John Garrett]], in order to further [[Centipede Project|Project Centipede's]] goal of creating its own super soldier, liberated Project Centipede's former associate [[Raina]] from prison, asking her in return to create a synthetic version of the lost GH.325 serum, using the vials of other GH serums that he had retrieved earlier. After accessing an [[Coulson's Team Hard Drive|encrypted hard drive]] containing all of the information gathered by [[Coulson's Team]], and researching blood samples from Coulson and Skye, [[Raina]] was able to duplicate something she believed was similar to GH.325, though she would not guarantee its results. She ultimately used the serum on a fatally injured [[John Garrett]] after his cybernetic implants were destroyed by an EMP activated by [[Leo Fitz]].<ref>''[[Ragtag|Agents of S.H.I.E.L.D.: 1.21: Ragtag]]''</ref>
   
Under the serum's effects John Garrett began writing a [[Words of Creation|complex code of symbols]], much to [[Grant Ward]]'s concern.<ref name="AoS122">''[[End of the Beginning|Agents of S.H.I.E.L.D.: 1.22: End of the Beginning]]''</ref><ref name="AoS205">''[[A Hen in the Wolf House|Agents of S.H.I.E.L.D.: 2.05: A Hen in the Wolf House]]''</ref>
+
Under the GH.325 serum's effects John Garrett began exhibiting immediate deterioration of his mental state, declaring that he had gained some higher form of cosmic awareness or clarity of mind, but spoke in cryptic statements regarding creation and evolution while deviating from his original goals and ideals, much to [[Grant Ward]]'s concern. Garrett also began carving the same [[Words of Creation|complex code of symbols]] as the previous GH.325 subjects, carving them into a large pane of glass.<ref name="AoS122">''[[End of the Beginning|Agents of S.H.I.E.L.D.: 1.22: End of the Beginning]]''</ref><ref name="AoS205">''[[A Hen in the Wolf House|Agents of S.H.I.E.L.D.: 2.05: A Hen in the Wolf House]]''</ref>
   
 
[[Phil Coulson]] started inscribing the code after seeing the portion written by John Garrett following the [[Battle at Cybertek]].<ref name="AoS122"/>
 
[[Phil Coulson]] started inscribing the code after seeing the portion written by John Garrett following the [[Battle at Cybertek]].<ref name="AoS122"/>
Line 41: Line 43:
 
[[Skye]], doing research into the code, learned from Ward that Garrett wrote them after his injection with GH.325.<ref name="AoS122" /> She confronted Coulson who eventually gave her full disclosure that he was writing the code and had Skye under observation to see if she was also. He revealed to her that it was theorized that he and Garrett reacted negatively to the drug because it was of extraterrestrial origin, but that she had no side effects because she might share its origins.<ref name="AoS205"/>
 
[[Skye]], doing research into the code, learned from Ward that Garrett wrote them after his injection with GH.325.<ref name="AoS122" /> She confronted Coulson who eventually gave her full disclosure that he was writing the code and had Skye under observation to see if she was also. He revealed to her that it was theorized that he and Garrett reacted negatively to the drug because it was of extraterrestrial origin, but that she had no side effects because she might share its origins.<ref name="AoS205"/>
   
  +
===Ineffective===
==Capabilities and Effects==
 
  +
Due to his deal with [[Ghost Rider]] to be able to kill [[Aida]], the GH.325 expired and Coulson was slowly dying from his old injury.<ref name="AoS512">''[[The Real Deal|Agents of S.H.I.E.L.D.: 5.12: The Real Deal]]''</ref>
GH.325 is a drug known to promote cellular growth that can be used to heal critical conditions, mortal wounds, and, in some cases, even revive the recently deceased.<ref name="AoS114"/>
 
   
 
==Capabilities==
In humans, the drug is known to have seriously damaging effects on the patient's psyche, with [[Memory Overwriting Machine|erasing or rewriting]] the subject's memories being the only way to alleviate the effects, but often with mixed results. The mental problems may stem from the introduction of information into the subject's sub-conscious, theorized to be a result of the introduction of genetic memories from the Guest Host corpse's DNA; in most of the known cases of the drug's use, the subject is shown to have gained a compulsive need to write portions of a [[Words of Creation|complex code]].
 
  +
{{Quote|Agent [[Phil Coulson|Coulson]] was injected with that and literally minutes later his wounds showed signs of cellular regeneration.|[[Jemma Simmons]] to [[Leo Fitz]]|T.A.H.I.T.I.}}
 
GH.325 is a drug known to promote rapid cellular regeneration that can be used to heal critical conditions, mortal wounds, and, in some cases, even revive the recently deceased.<ref name="AoS114"/>
   
 
In humans, the drug is known to have seriously damaging effects on the patient's psyche, with [[Memory Overwriting Machine|erasing or rewriting]] the subject's memories being the only way to alleviate the effects, but often with mixed results. The mental problems stem from the introduction of information into the subject's sub-conscious, theorized to be a result of the introduction of genetic memories from the Guest Host corpse's DNA; in most of the known cases of the drug's use, the subject gains a compulsive need to write portions of a [[Words of Creation|complex code]] and develops an obsession with determining their meaning.
In [[Skye]]'s case, there were no mental side-effects such as hypergraphia. The reason for Skye's apparent immunity to the drug's mental effects is unknown, but it is implied she has non-human origins.
 
   
  +
In [[Skye]]'s case, however, there were no mental side-effects due to her being an [[Inhumans|Inhuman]] and sharing a connection to [[Kree]] biology, which was used to create the drug.
In several known cases of the drug's use, there was no detectable trace of the drug's presence in the patient's body immediately following the period of recovery, making it difficult to properly research the drug's exact effects or to replicate it.<ref name="AoS115"/> However, after months of research, [[Jemma Simmons]] eventually found a way to detect if a patient was a recipient of GH.325.<ref name="AoS207"/>
 
  +
 
In several known cases of the drug's use, there was no detectable trace of the drug's presence in the patient's body immediately following the period of recovery, making it difficult to properly research the drug's exact effects or to replicate it.<ref name="AoS115"/> However, after months of research, Agent [[Jemma Simmons]] eventually found a way to detect if a patient was a recipient of GH.325.<ref name="AoS207"/> In any case, enough GH.325 lingered in [[Daisy Johnson]]'s bloodstream after over two years for her blood to adequately substitute that of a Kree for [[Hive]]'s [[Absolution Virus|recreation]] of the experiments that created Inhumans.<ref name="AoS320">''[[Emancipation|Agents of S.H.I.E.L.D.: 3.20: Emancipation]]''</ref>
   
 
==Appearances==
 
==Appearances==
  +
{| class="mw-collapsible mw-collapsed wikitable" width="100%"
  +
!Appearances for GH.325
  +
|-
  +
|
  +
In chronological order:
 
*''[[Agents of S.H.I.E.L.D.]]''
 
*''[[Agents of S.H.I.E.L.D.]]''
 
**''[[Agents of S.H.I.E.L.D./Season One|Season One]]''
 
**''[[Agents of S.H.I.E.L.D./Season One|Season One]]''
Line 63: Line 74:
 
***''[[A Hen in the Wolf House]]'' <small>(mentioned)</small>
 
***''[[A Hen in the Wolf House]]'' <small>(mentioned)</small>
 
***''[[The Writing on the Wall]]'' <small>(mentioned)</small>
 
***''[[The Writing on the Wall]]'' <small>(mentioned)</small>
  +
***''[[Afterlife (episode)|Afterlife]]'' <small>(mentioned)</small>
  +
**''[[Agents of S.H.I.E.L.D./Season Three|Season Three]]''
  +
***''[[Failed Experiments]]'' <small>(mentioned)</small>
  +
***''[[Emancipation]]'' <small>(mentioned)</small>
  +
**''[[Agents of S.H.I.E.L.D./Season Four|Season Four]]''
  +
***''[[Identity and Change]]'' <small>(indirectly mentioned)</small>
  +
**''[[Agents of S.H.I.E.L.D./Season Five|Season Five]]''
  +
***''[[The Real Deal]]'' <small>(mentioned)</small>
  +
***''[[Best Laid Plans]]'' <small>(indirectly mentioned)</small>
  +
|}
  +
  +
== Trivia ==
  +
*[[John Garrett]] called it "Jesus juice" for being able to bring back the dead.
   
 
==References==
 
==References==
 
{{Reflist}}
 
{{Reflist}}
 
[[Category:Items]]
 
[[Category:Items]]
  +
[[Category:Medicaments]]
 
[[Category:Agents of S.H.I.E.L.D. Items]]
 
[[Category:Agents of S.H.I.E.L.D. Items]]
 
[[Category:Project T.A.H.I.T.I.]]
 
[[Category:Project T.A.H.I.T.I.]]

Revision as of 03:44, 22 May 2020

"The drug that healed Skye and brought Coulson back to life."
Raina[src]

GH.325 is one of a number of drugs derived from the blood of a Kree corpse code named "G.H.". When administered, the drug causes rapid healing by promoting advanced cellular regeneration, healing severe and fatal wounds, and in some cases can even revive the recently deceased.

History

Origins

"I believe Garrett and I had a negative reaction to the alien DNA in our system. Maybe you didn't because it was already there."
Phil Coulson to Skye[src]

In the closing days of World War II, the Strategic Scientific Reserve conducted a raid on one of the final active HYDRA bases, a secure research facility. After taking control of the base, the Strategic Scientific Reserve took custody of all assets and artifacts within the base, among which was the corpse of a Kree, which had been part of an attempted invasion force that visited Earth thousands of years ago and was left behind.[1]

The corpse, given the designation "G.H.", was transferred to a facility known as the Guest House where it was studied intensively. From the G.H.'s bodily fluids, scientists were able to synthesize a number of advanced drugs with varying effects on human biology, including the serum GH.325, a serum with the potential to revive the recently deceased.[2]

Project T.A.H.I.T.I.

"We need to shut down the program."
"This isn't a failure, Agent Coulson. It's a first step. We rejuvenated life."
Phil Coulson and Goodman[src]

Under Project T.A.H.I.T.I., the drug was intended to be used to heal an Avenger should one become seriously wounded or die in the line of duty.[3]

The supervisor of the project, S.H.I.E.L.D. agent Phil Coulson, authorized testing of the drug on other agents, including one diagnosed with a terminal illness. At first, the agents were closely watched and showed signs of complete recovery; however, they each eventually developed the same form of psychosis, demonstrating a persistent need to carve a series of unusual symbols of which they had no prior knowledge, and an unhealthy obsession with determining the symbols' meaning. Doctor Goodman, one of the chief medical scientists working on the project, suggested erasing the memories of all of the patients regarding the project to erase the genetic memories implanted on them by using the GH.325, and to give them new identities so they could continue living normal lives.[4]

Having witnessed the psychological breakdown of all of the test participants and the unethical methods used to heal them, Coulson made a final report in which he appealed to S.H.I.E.L.D.'s director, Nick Fury, to have Project T.A.H.I.T.I. terminated due namely to the horrific side effects of the GH.325 serum and its related procedures, while also resigning from his position as supervisor.[3]

Resurrections and Secrets

"In the history of bad ideas, this is light years ahead of everything."
"No, trying to bring dead agents back to life using alien blood blows everything else away."
Skye and Phil Coulson[src]

When Agent Phil Coulson himself was fatally stabbed through the heart by the rogue AsgardianLoki, S.H.I.E.L.D. Director Nick Fury used his connections to allow Coulson to undergo a series of intensive surgeries at the Guest House that brought him back to life after being dead for several days. Among the processes used on Coulson was the administering of the GH.325 serum, which had the effect of completely regenerating his eviscerated heart tissue. However, the use of this serum, along with all other details of his resurrection, was kept secret from Coulson after his memories of the operation were erased.[5]

Later, during a mission carried out by Agent Coulson's personal team, Skye, an inexperienced asset recruited by Coulson, was shot twice in the abdomen and left for dead. This event deeply affected Coulson, who felt personally responsible, motivating him to research all aspects of his mysterious resurrection in order to find something capable of saving Skye's life. His search led him and a small team to execute an unwilling raid on the Guest House in search of the drug. While the GH.325 was successful in restoring Skye's health, the raid resulted in the destruction of the Guest House, burying all existing stock of the drugs, along with its source,[2] excluding a few vials, containing other GH formulas, which were retrieved by John Garrett in secret.[6]

GH Cables

Body fluids being harvested from G.H. to create GH.325

Upon learning of the miracle drug's true source, Agent Coulson became extremely apprehensive of its use and possible side effects on himself and Skye. At his behest, Coulson had his team member and S.H.I.E.L.D. scientist Jemma Simmons actively monitor the serum's effects on Skye. Personally interested in how the GH.325 could benefit humanity, Simmons hoped to recreate the drug by repeatedly analyzing Skye's blood. However, she was unable to discover anything unusual in the blood samples, even when comparing them to Coulson's blood. When she asked Coulson to send blood samples to their Headquarters in order to analyze them and mend her lack of available resource, Coulson denied permission without explaining to Simmons the real reason for doing so.[7]

Agent Simmons continued to research and analyze the drug in secret, eventually gaining access to a better lab at the Hub. Unfortunately, before much progress could be made, Simmons was interrupted by the Assault on S.H.I.E.L.D. by HYDRA sleeper agents.[8] Following the assault, Grant Ward passed on an encrypted hard drive containing all of Simmons' GH.325 research to his HYDRA superior John Garrett.[6]

Re-created

"You've re-created GH-325."
"Almost. We've distilled the genetic components of all the previous samples down to one single vial."
"And it'll do what we talked about?"
"It should regenerate and heal cells, just like it did in Skye and Coulson."
Grant Ward, Raina, and John Garrett[src]

John Garrett, in order to further Project Centipede's goal of creating its own super soldier, liberated Project Centipede's former associate Raina from prison, asking her in return to create a synthetic version of the lost GH.325 serum, using the vials of other GH serums that he had retrieved earlier. After accessing an encrypted hard drive containing all of the information gathered by Coulson's Team, and researching blood samples from Coulson and Skye, Raina was able to duplicate something she believed was similar to GH.325, though she would not guarantee its results. She ultimately used the serum on a fatally injured John Garrett after his cybernetic implants were destroyed by an EMP activated by Leo Fitz.[9]

Under the GH.325 serum's effects John Garrett began exhibiting immediate deterioration of his mental state, declaring that he had gained some higher form of cosmic awareness or clarity of mind, but spoke in cryptic statements regarding creation and evolution while deviating from his original goals and ideals, much to Grant Ward's concern. Garrett also began carving the same complex code of symbols as the previous GH.325 subjects, carving them into a large pane of glass.[10][11]

Phil Coulson started inscribing the code after seeing the portion written by John Garrett following the Battle at Cybertek.[10]

Skye, doing research into the code, learned from Ward that Garrett wrote them after his injection with GH.325.[10] She confronted Coulson who eventually gave her full disclosure that he was writing the code and had Skye under observation to see if she was also. He revealed to her that it was theorized that he and Garrett reacted negatively to the drug because it was of extraterrestrial origin, but that she had no side effects because she might share its origins.[11]

Ineffective

Due to his deal with Ghost Rider to be able to kill Aida, the GH.325 expired and Coulson was slowly dying from his old injury.[12]

Capabilities

"Agent Coulson was injected with that and literally minutes later his wounds showed signs of cellular regeneration."
Jemma Simmons to Leo Fitz[src]

GH.325 is a drug known to promote rapid cellular regeneration that can be used to heal critical conditions, mortal wounds, and, in some cases, even revive the recently deceased.[2]

In humans, the drug is known to have seriously damaging effects on the patient's psyche, with erasing or rewriting the subject's memories being the only way to alleviate the effects, but often with mixed results. The mental problems stem from the introduction of information into the subject's sub-conscious, theorized to be a result of the introduction of genetic memories from the Guest Host corpse's DNA; in most of the known cases of the drug's use, the subject gains a compulsive need to write portions of a complex code and develops an obsession with determining their meaning.

In Skye's case, however, there were no mental side-effects due to her being an Inhuman and sharing a connection to Kree biology, which was used to create the drug.

In several known cases of the drug's use, there was no detectable trace of the drug's presence in the patient's body immediately following the period of recovery, making it difficult to properly research the drug's exact effects or to replicate it.[7] However, after months of research, Agent Jemma Simmons eventually found a way to detect if a patient was a recipient of GH.325.[4] In any case, enough GH.325 lingered in Daisy Johnson's bloodstream after over two years for her blood to adequately substitute that of a Kree for Hive's recreation of the experiments that created Inhumans.[13]

Appearances

Appearances for GH.325

In chronological order:

Trivia

  • John Garrett called it "Jesus juice" for being able to bring back the dead.

References