Doctor List use the plane to travel the world and hunt down enhanced individuals. He was particularly focused on finding an individual who was able to teleport and attempted to track him using Quantum Entanglement signatures.
When Sunil Bakshi reached out List used the plane to travel to meet him. Phil Coulson had Deathlok attend the meeting so he could use his hardware to monitor the conversation. Bakshi was able to convince List that he was still loyal to HYDRA after he offered to turn the Deathlok over to him. When it became clear that Bakshi had deviated from the plan, Deathlok had activated his weapons systems and prepared to take out the plane's crew but stopped when he received orders to stand down from Coulson.
During the meeting the plane’s crew detected another Quantum Entanglement signature in Milwaukee. List ordered that the plane traveled to intercept the enhanced individual and had Bakshi prepare to weed the mission to capture the subject.