Drax the Destroyer's Knives are Drax the Destroyer's primary weapons in combat.
Seeking to destroy Ronan the Accuser, Drax had used his knives to threaten the Knowhere Dispatcher, forcing him to send a message to Ronan to bring him there. Once Ronan arrived with his army of the Sakaarans, Drax greeted him with his knives ready. During their battle, Drax was unable to land a killing blow against Ronan, and was eventually disarmed and defeated.
Drax later used the knives to battle Thanos on Titan, with him notably landing a strike that even if only barely, injured the Titan minorly and caused him to flinch. He then dueled Thanos alongside Doctor Strange, who used Eldritch Magic to craft a sword to allow him to fight Thanos. However, Drax's use of his knives was only effective for a short period, as Thanos swiftly overwhelmed him and incapacitated him briefly with a powerful punch that send him through stones even though Drax used his knives to block it. The knives were later destroyed alongside Drax.