Using knowledge previously obtained from the Darkhold, Holden Radcliffe and Aida redesigned the Framework to create a virtual reality where the user could correct their greatest regret. They then uploaded the consciousness of Melinda May into the Framework and recreated her life up until the ill-fated S.H.I.E.L.D. mission in Bahrain, which originally ended with May retiring from field work after being forced to kill Katya Belyakov.
As a result of the Framework's new capabilities, May experienced a version of the mission that ended with her saving the virtual Katya. Following the rescue mission, S.H.I.E.L.D. brought Katya back to the United States, where she began attending school in Cambridge, Massachusetts. It was suspected by Phil Coulson that HYDRA had intentionally engineered this mistake, knowing what the consequences would be and fully intending to capitalize on them.
The public's response resulted in S.H.I.E.L.D. shutting down and HYDRA conquering the nation. The Cambridge Incident was later taught to future generations as a reminder that the needs of the state are more important than the needs of the individual.
Since Katya Belyakov was an Inhuman, institutionalized bigotry and persecution against Inhumans formed the backbone of HYDRA's new world order. Because her mistake was responsible for this persecution, Melinda May became a hated figure among Inhumans.
- Agents of S.H.I.E.L.D.