Aerodynamic Marvel Rescue
Tony Stark, using his newly created identity as Iron Man to establish world peace, was asked by General Turner at the Pentagon to evacuate to Egypt a pilot shot down in the Democratic Republic of the Congo.
Stark learned that those responsible for the attack were members of the Congolese Army, in league with the Ten Rings, and that the pilot was part of a field test of a prototype vehicle designed by Justin Hammer.
The real objective was to make Stark kill the Congolese Army members masquerading as an act of self-defense during the rescue, but Stark was able to see pass his lies and rescued the pilot without bloodshed. General Thaddeus Ross, officer in charge of the project and infuriated by the outcome of the events, ordered Stark to land at Cairo, with Stark cutting the communication to show his weariness of being manipulated by the United States Armed Forces.
Stark arrived at Cairo, placing the pilot under medical care, and informing Ross about his knowledge of their intentions of making him kill the soldiers. Stark conducted a research on Ross while traveling from the Democratic Republic of the Congo, learning about his role in experiments of genetic enhancements for military exploitation, and warned him not to put any innocent life in harm just to advance a military agenda before leaving Egypt to return to the United States.
S.H.I.E.L.D. agents John Garrett and Antoine Triplett visited one of S.H.I.E.L.D.'s safehouses in Cairo during one of their missions. This particular safehouse impressed the agents, later comparing it to the one in Sydney, as Cairo's safehouse even had luxury thousand-thread-count sheets, with a sateen finish.
Cairo was one of the intended targets of Project Insight, as some of its citizens were deemed a threat for HYDRA's plans. Jasper Sitwell explicitly referred to a TV anchor living in Cairo as one of the targets for Insight. The city was not shot as Captain America and his allies were able to change the intended targets and stop HYDRA in time.