Full Hard Reboot, Just bring in some of the characters from the universe into the Prime MCU universe and keep the story, you can bring back some of the current Dead characters (as long as they are vastly different or possibly Younger) even with the same actors (Just used the De-age tech for the current actors if they wanted to keep playing the same characters).

Also Kill off All Kangs in Doomsday. Keep Immortus and Kid Immortus Alive , they are too powerful to be killed off-screen.

Full Reboot. It wouldn't make sense for Marvel to do something like that

What everyone else said

They probably will do this, but I'd greatly prefer if they didn't have a huge ensemble cast, and a huge CGI battle, and tons of special effects. We don't need another Endgame, we need something new.