This is more not getting why they cast him in the first place. Not only as a major draw for a personal villain against our MCU heroes with the face of their fallen icon, but also due to RDJ having nearly played Doom for the 2005 Fantastic Four. Therefore being a legacy casting of a project that didn't make it like Channing Tatum getting his moment to get to play Gambit.
And also because it is a multiversal Avengers threat version, the official MCU Earth version post-Secret Wars can still exist and obviously would be a different actor due to the person with RDJ's face on the MCU Earth being Iron Man. So yes, they could just cast Cillian Murphy after at some later point.