As it confirmed a few days ago, Spider-Man 4 will circulate after Avengers: Doomsday. I believe that in Avengers: Doomsday Spider-Man will die but the symbiote (No Way Home Symbiote) will save him, making a new code to help Knull to set free. Knull found Venom/Eddie because he travelled to the Multiverse. So, if Avengers: Doomsday will be a Multiversal story, Knull will found Peter after he returns to his universe and he will fight with him in Spider-Man 4.