They would probably think it's weird that his conflict with them stemmed from both of them holding grudges against Tony Stark.

I mean they would see them as another villain

We do know that both Vulture and Mysterio had a beef with Tony so they might not know who Tony is

The weirdest thing is that Mysterio probably would’ve appeared in Peter 2’s reality at some point, Quentin Beck was a theater usher in the second Sam Raimi Spider-Man film.

https://youtube.com/shorts/ClUdthCjIGQ?feature=shared