“Cut off one head, two more shall take its place” is their motto for a reason I suppose. I don’t think any story will focus on them going forward though, maybe a cameo from a Hydra agent? Other than that, I don’t think so.

HYDRA itself is done as a main threat but I think their influence will continue at least in the Captain America franchise through characters like Baron Zemo

Agents of S.H.I.E.L.D. did HYDRA to death lol

Agreed with above, we’ll likely hear plenty of mentions; just this year we’ve had connections in the form of Wilfred Nagel and the North Institute. But in terms of actual story (at least in the main timeline MCU), likely not.

I wouldn’t be surprised if Red Skull came back and did something, but it wouldn’t be HYDRA related.

They might still be around, but for now, as far as we know, HYDRA was destroyed by SHIELD at the end of Season 3 back in Spring 2016. They be dead.