i think a wandavison season two entirely depends on how season one ends

I agree with @WitchyAlonzo .

I think it highly depends on the ending of s1. But even if the end doesn't make a s2 impossible I personally don't like the idea of a 2nd season and I think it wouldn't make much sense. Don't get me wrong, I'm loving WV a lot but since the whole series is about Wanda and Vision and her dealing with Vision's death and making her own reality bubble, I think that there wouldn't be much room for any other plot in a following season.

I know a lot of people want house of M and I think if that happens, it shouldn't be in this series.

I personally think they could play a bit more in the sandbox of TV, specially as they only did sitcoms. I'd like to see how they'd parody/homage Reality TV, Travel shows, Contest Shows, etc. I really think there is an opportunity for it, if they'd ever decide to do the Mojo character, or Arcade, as either of them could do this show well.

And if we wanted to continue this more mystical side, there are certainly a couple of shows like Supernatural, Vampire Diaries and others that I'm sure they could parody. However, I do think that if they were to do a Season 2, it should be more "House of M"-y, featuring supporting characters in their "perfect show", ie Monica doing Nextwave as a Brooklyn 99 sort of thing, Jimmy Woo with his Agents of Atlas as a kids show (alla Dora), and things like that.

@Angel Gro You're saying they could do other genres of TV if they continue the show?

@BlueDaly Yeah, just like how the Captain America trilogy did different genres in each movie

That would be interesting to see...