I agree with @WitchyAlonzo .
I think it highly depends on the ending of s1. But even if the end doesn't make a s2 impossible I personally don't like the idea of a 2nd season and I think it wouldn't make much sense. Don't get me wrong, I'm loving WV a lot but since the whole series is about Wanda and Vision and her dealing with Vision's death and making her own reality bubble, I think that there wouldn't be much room for any other plot in a following season.
I know a lot of people want house of M and I think if that happens, it shouldn't be in this series.
