Well if anything they will probably be featured in an episode of “What If..”. It’s probably best for MCU focus on other groups right now. They have many great villains that weren’t part of Hydra, to not yet appear.
I doubt it, and to be honest, I'm glad the chances are slim. After watching Agents of S.H.I.E.L.D, which focused heavily on Hydra for 4 seasons, I'm kind of tired of that storyline. However, if that's your cup of tea and you haven't seen Agents of S.H.I.E.L.D, 10/10 highly recommend watching it. It's a great show anyway, though.