I love Jemma Simmons, what a show of resilience. Kidnapped and taken time and time again, and yet remaining strong throughout all of it. She's such an emotionally stable and present character, demonstrated once she jumped out of the Bus, accepting the importance of saving her friends. That episode had me terrified. The dynamic she and Fitz have throughout the show, later with the addition of Deke, is so brilliantly scripted and done to make them the best couple in the show, and later the best family. Plus, Elizabeth Henstridge deserves every award ever for giving us one of, if not the best episode in the entire series, the Simmons-centric 4,722 Hours.
Now onto the thing I want to analyze, I strongly believe that she and Fitz (if you do a character discussion for Fitz, I'll go more into him, but I want to focus on Simmons) are autism-coded (as in, meant to be autistic). Let's start with the obvious: She and Fitz both hyper fixate on their fields. Hyperfixation is a very common trait with autistic people, and when she talks about what's happening, she often assumes those around her also understand the complex science without any gauge for what other people do and don't know. Hence Coulson constantly having to ask her to simplify her language.
Next, in the episode with the Chitauri virus (the one I call the crying episode), Simmons insists that the cure she's making is an antiserum rather than a vaccine, with being overcorrect being another really common trait. In the episode with the train, we see this manifest differently as Simmons has developed an overly complicated backstory for herself and Coulson's covers, not realizing how much information is too much that would be shared in a normal conversation like the one she pretends to have. As Simmons went undercover in HYDRA, she once again proved herself unable to simulate normal conversation, seemingly needing another person acting genuine to imitate. This is called masking, and girls are usually far better at it than guys (hence why girls tend to go undiagnosed). She needs Coulson's advice on how to make friends, even as a grown woman.
When Simmons returned from cover, she expected herself and Fitz to bounce right back to the way things were, also common in autistic people. It took her a long to accept that things had changed and that she needed to accept it. Her trip to Maveth further demonstrated her hyper fixation on science and the way she focuses so strongly on her relationships with other people, both Fitz and Will.
I mentioned masking, but let's talk about it. Simmons has proven herself time and time again to be incredibly similar to Fitz, both socially and otherwise. However, when around other people, she has been shown to be better at communicating with them at first (when they first meet Radcliffe, for example). That's called masking, and girls are far better at it than boys, furthering the case. Despite this, she has been shown to experience what can be described as shutdowns in extreme cases (like when she had to revive May from the "ghost" infection or when she made the jump in the season six premiere without the rest of the group wanting to).
The Framework further shows how she gets when things aren't right, desperately trying to correct things like hating Ward. Autistic people have a strong need for things to be as they should be, and will try to correct things when they're wrong, regardless of whether that's in their control.
Furthermore, when Simmons gets high on the space candies, she is reminded of Fitz by seeing him in a monkey suit, remembering an extremely small detail about Fitz, even when on psychedelic drugs, that most people wouldn't remember. This kind of memory is super common amongst autistic people, despite inability to remember bigger, more important things. While Simmons does not portray this latter part often (although she does for a moment when she forgets to tell Fitz about Deke at the end of the mind prison episode), it's not a disqualifier since most of the studying on autism symptoms were done on men, and women tend to show slightly different symptoms.
In the mind prison, she literally experiences age regression when faced with a scary situation, something incredibly associated with autistic people even if it's not always correct.
Throughout Season 7, Simmons is shown to have matured a lot after becoming a parent (even though we don't know that yet), although she still uses science babble and literally has a major memory removed from her head. She focuses so strongly on her inability to remember that she (again, shown to us quite literally), manifests it. Then, once DIANA is replaced and we see her true self, she becomes focused on the little details of wanting a suit like Daisy's unlike the bigger picture of escaping the Chronicoms, and it really shows how she is.
Fitz and Simmons are both very clearly autism-coded, and as an autistic person, I appreciated having two characters I can relate to so strongly in a superhero show. It was really cool seeing the two of them on screen together. My (neurotypical but very similar to me) girlfriend and I both refer to each other as "Fitz" and "Simmons" respectively, and this is a huge part of why. Seeing characters I can relate to like this made me feel so good about myself always (except for the episode where Fitz has a split in his psyche, that gave me a panic attack but that's another story for another day), and I appreciate Simmons so much as a character I am sad to see her and Fitz go especially. They were always my favorites.