This would be a very cool thing to be true (which there's no strong confirmation for), due to the many possibilities that could play out.
Tom Cruise, who was once considered to play Iron Man, would be a fun inclusion, but we could also see Tobey Maguire's Spider-Man, other people who were almost cast in roles, or even just MCU actors playing different versions of their character.
We are exploring the Multiverse, so it would be very underwhelming if we didn't get to see alternate characters make appearances.