Louis D'Esposito es el co-presidente de Marvel Studios y el productor ejecutivo de Iron Man, Iron Man 2, Thor, Marvel One-Shot: The Consultant, Captain America: The First Avenger, Marvel One-Shot: A Funny Thing Happened on the Way to Thor's Hammer, The Avengers, Marvel One-Shot: Item 47, Iron Man 3, Thor: The Dark World, Marvel One-Shot: All Hail the King, Captain America: The Winter Soldier, Guardians of the Galaxy, Agent Carter, Avengers: Age of Ultron, Ant-Man, Captain America: Civil War, Doctor Strange, Guardians of the Galaxy Vol. 2, Spider-Man: Homecoming, Black Panther, Avengers: Infinity War, Ant-Man and the Wasp, Captain Marvel, Avengers: Endgame, Spider-Man: Far From Home, WandaVision, The Falcon and the Winter Soldier, Loki, Black Widow, What If...?, Shang-Chi and the Legend of the Ten Rings, Eternals, Spider-Man: No Way Home, Doctor Strange in the Multiverse of Madness, Thor: Love and Thunder, Black Panther: Wakanda Forever, The Marvels, Guardians of the Galaxy Vol. 3, The Fantastic Four: First Steps y Blade.
Él también dirigió Marvel One-Shot: Item 47, Marvel One-Shot: Agent Carter y el episodio Now is Not the End de la serie de televisión Agent Carter.
Él también fue entrevistado en el documental Marvel 75 Years: From Pulp to Pop.
