Board Thread:General Discussion/@comment-1031724-20170228063207/@comment-27020644-20170228185508

Well, we really don't know if the Red Skull is dead, plus Fury held the Tesseract and nothing happened to him. So based on that, we really don't know what the Space Stone does. We have not seen anyone touch the actual Stone, just the Tesseract.

As for the Soul Stone, it probably steals the holder's soul. That's what the Soul Gem did in the comics.