Destruction of the Framework

The Destruction of the Framework was a successful attempt by Aida to destroy the Framework, as she had used the Darkhold to create a new body so saw no further use of it.

Change in Purpose
"I knew the machine could create matter, but Aida's gone beyond that. She's found a way to generate living matter... human tissue. She wants to make herself into a real person." "A real girl, as opposed to?" "A simulated consciousness. She... She wants to circumvent her programming. Every step has been towards that goal. The Framework, Radcliffe, Fitz. We have to stop her."

- Jemma Simmons and Antoine Triplett (Framework)

Daisy Johnson and Jemma Simmons soon discovered the fascist regime ruled by HYDRA, but were surprised to discovered how different their friends were inside the Framework. Leo Fitz was a ruthless doctor and second-in-command in HYDRA, Melinda May was a high-ranking operative in HYDRA, Phil Coulson was a history teacher and Alphonso Mackenzie lived with his daughter. The two joined S.H.I.E.L.D., which operated as a resistance led by Jeffrey Mace, who was an Inhuman in the Framework. With the aid of virtual incarnations of people who were dead in the real world, like Grant Ward, Antoine Triplett and Burrows, Johnson and Simmons tried to convince their friends about the real world, while fighting against HYDRA and its leader, Madame Hydra, Aida's alias in the Framework at the same time. As Johnson and Simmons almost succeeded in gathering all their friends, Mace was killed in the Framework, killing him in the real world as well. Simmons then realized Aida's true plan for the Framework: In order to create a human body for herself, Aida needed a machine constructed out of Quantum Batteries. Putting the agents in the Framework was to prevent them from stopping her plan, and also using Fitz to design the machine through Project Looking Glass. Once Aida's plan was fulfilled, she could kill them all inside the Framework.

Eventually, Johnson and Simmons managed to return to the real world with Coulson, May and Fitz, but without Mackenzie, who decided to stay with his daughter. Aida's plan for the Framework succeeded, as she created for herself a living human body. This body also granted Aida a number of superhuman abilities, obtained from Fitz's experiments on captured Inhumans.

Digital Apocalypse
"Aida's shutting down the Framework. It's collapsing on itself. This is what happens when you piss off your creator."

- Holden Radcliffe to Yo-Yo Rodriguez

Aida decided to delete the Framework and all its contents. Meanwhile, Elena Rodriguez entered the Framework in order to convince Alphonso Mackenzie to exit it. She woke up in the middle of the world's crisis. With the help of Holden Radcliffe, she found Mackenzie who still refused to leave. As more and more details were deleted from the Framework, Daisy Johnson created for Rodriguez and Mackenzie a way out of there. Only after Hope Mackenzie was deleted too, Mackenzie agreed to leave. As the last person in the Framework, Radcliffe accepted his death and was deleted before the Framework world was erased completely.