Board Thread:General Discussion/@comment-27136464-20151101154200/@comment-1894786-20160222052333

Creators have confirmed it's part of the X-MCU (X-Men Cinematic Universe) rather than the MCU. The movie itself, however, does put one foot in each universe. Though the ties are stronger to the X-MCU, Deadpool does reference Nick Fury and fights on top of a Helicarrier, which are clear ties to the MCU.

If we ever regain the rights to Deadpool (we meaning the general we, AKA the fans of the MCU), I'm sure they'd retcon the story into being part of the MCU, because there's no way in hell they'd be able to top that movie with their own version of Deadpool OR successfully replace Ryan Reynolds with anyone else. Though... I don't know how they'd handle Negasonic and Colossus.