Jemma Simmons

"You're a real miracle worker."

- Antoine Triplett

Jemma Simmons is an English-born S.H.I.E.L.D. agent and scientist. A genius, she is one of the youngest and most prominent members of S.H.I.E.L.D.’s research division, along with her friend and partner, Leo Fitz. She, along with Fitz were recruited to Coulson's Team and worked with them on all of their missions. While on the team, Simmons became friends with teammates Skye and Grant Ward. During the HYDRA Uprising, Simmons was an active participant in hunting for John Garrett and the rest of the Centipede Project. She was shocked and saddened to learn that Ward had been a member of HYDRA. Despite the events surrounding the Battle at Cybertek and Fitz's severe injury, Simmons stayed with the team to help rebuild S.H.I.E.L.D. as Nick Fury requested.

As Coulson began to rebuild S.H.I.E.L.D., she became aware that her presence was impeding Fitz's healing and took an undercover assignment to infiltrate HYDRA but returned to S.H.I.E.L.D. when Raina broke her cover. She aided the team in their search for the Kree City and in other operations. When their base was attacked by another S.H.I.E.L.D. faction led by Robert Gonzales, she remained loyal to Coulson. After the War against the Inhumans, Simmons found herself teleported to another world after being swallowed by the Kree Monolith. In the six months she spent there, she met and bonded with a fellow stranded human, astronaut Will Daniels, until she was brought back to Earth by Fitz and S.H.I.E.L.D. Simmons then dedicated her time to attempting to reopen the portal, determined to bring back Daniels. But she heard from Fitz that he was killed by the dark Inhuman as he returned from the other planet.

Early Life
"Why did you join S.H.I.E.L.D. in the first place?" "I was a 17-year-old girl with two Phds and a million questions. S.H.I.E.L.D. had the resources to help me answer them."

- Sunil Bakshi and Jemma Simmons

Jemma Simmons was born on Friday, September 11th, 1987 in Ashburton, Devon, England. During her youth, Simmons was bed-ridden by ; her father, to relieve her boredom, would place her bed outdoors so they could stargaze together. A 17-year old biochemistry genius with two PhD's, Jemma Simmons started attending the S.H.I.E.L.D. Academy of Science and Technology in 2004, where she met who would become her best friend, the engineering genius Leo Fitz. One of her main reasons for joining was to get answers to millions of questions. Among their instructors were Professor Vaughn and Professor Franklin Hall, who taught chemical kinetics during their second year.

Simmons and Fitz graduated from the academy three years early. Wanting to see more than the inside of a lab, and against the advice of Professor Vaughn, Simmons convinced Fitz to seek out a field assignment.

Field Work
"You're easily the most beautiful thing I've seen in a thousand years."

- Elliot Randolph

Simmons and Leo Fitz were recruited by Agent Phil Coulson to be the science crew for a new team he was putting together. Stationed on the Bus, the pair have designed specialized equipment and compounds on the fly in various emergency situations.

Their first foray into the field involved the case of Michael Peterson, a man in danger of exploding due to his use of the volatile Centipede Serum. Peterson was saved in part by Simmons' efforts to create a Centipede counter-agent for Peterson.

Simmons first faced danger in the field in Peru, where the team was investigating an 0-8-4. Simmons and the team escaped Peruvian rebels only to face an armed takeover of the Bus. Working with the team, she helped take back the Bus and secure the old HYDRA weapon. Coulson's team received a message that a S.H.I.E.L.D. lorry transporting cargo had been attacked by a mysterious and invisible enemy. The team investigated and Simmons discovered that a rare element called Gravitonium was the cause of the attack. The team then learned that it was in fact Fitz and Simmons' former mentor, Franklin Hall, who was the cargo and he had been kidnapped by billionaire Ian Quinn. The team were sent in to rescue Hall from Quinn's island home, but Coulson was forced to kill him, despite Fitz and Simmons' pleas, when he threatened to destroy the entire island and everyone on it. While investigating a mysterious death in Wrigley, Pennsylvania, Simmons was infected with a lethal alien virus passed along from a Chitauri Helmet. After what appeared to be a final failed attempt at a cure, Simmons threw herself from the Bus in flight in order save her team from the virus' effect. Fortunately for Simmons, the cure was actually effective and teammate Grant Ward caught her in mid-flight and parachuted them both to safety. At the Hub, Simmons assisted Skye with finding out about Fitz and Ward's mission. However, Simmons was discovered by agent Sitwell and tried to lie her way past him. she was then forced to use the Night-Night Gun on him. She then joined May, Skye, and Coulson in extracting Fitz and Ward. Later, she helped the team cleanup the Battle of Greenwich and aided them in their search for the Berserker Staff. Simmons and Fitz visited StatiCorp after its particle accelerator exploded and scanned the area. Simmons then discovered that the StatiCorp explosion actually ripped a portal between worlds and that the "demon" that the team was investigating was Tobias Ford. They learnt that Ford was trapped between worlds as a ghostly figure and was attacking anyone who got near the girl he loved Hannah Hutchins. Ford attacked the plane and managed to ground it but was ultimately stopped by Melinda May and Hutchins and was allowed to die. When the team continued tracking the group who created the Centipede Serum, Centipede Project, they were teamed up with Mike Peterson to find this organisation. But later Centipede Project kidnapped Phil Coulson. Simmons helped the team to find him until they rescued him from the hands of the organization. Simmons and Fitz were invited to revisit the S.H.I.E.L.D. Academy where they graduated when there was an attack on some of the students there. They were greeted by Anne Weaver and asked to give the students a speech about their own experiences working for S.H.I.E.L.D.. During the speech one student named Donnie Gill was frozen in ice and nearly killed in a similar attack. Simmons and Fitz managed to save his life and continued their investigation. They later learned that it was in fact Gill and another student, Seth Dormer, who had arranged the attacks on themselves to draw Fitz to the academy so he could inadvertently help them finish their design for a Freezing Device. The team managed to track down the pair, Dormer was killed by a lightning strike and Gill was arrested.

Learning to Assert Herself
"No. That's an order." "That's not a good enough reason! I have a duty to you, sir, as my commanding officer, but I also have a duty as a S.H.I.E.L.D. scientist to pursue this, to save lives!"

- Coulson and Simmons arguing about GH.325

Simmons decided that since she could not lie well, she would learn to act. When Coulson's Team went after Ian Quinn by tracking the Cybertek Prosthetic Leg he bought, Simmons acted as Coulson's daughter in order to distract the carrier of the package to put tracking dust on him.

Simmons' medical knowledge saved Skye as Simmons ordered her teammates to put her in a Hyperbaric Chamber after she was shot twice in the stomach.

Antoine Triplett arrived with John Garrett in order to take Ian Quinn to the Fridge. While Garrett, Coulson, Grant Ward, and Leo Fitz raided the Guest House to find GH.325 in order to save Skye from her fatal injuries, Simmons and Triplett monitored Skye and got to know each other. Ultimately, Fitz brought one sample of the drug and Simmons used it to heal Skye.

With the only sample of the drug used and the Guest House destroyed, Simmons worked tirelessly to try to find a way to reproduce it. When Coulson ordered her not to share her research with anyone, Simmons yelled at him for not realizing how important this drug was. Eventually, she yielded, but she was determined to reproduce GH.325.

Meanwhile, her feelings toward Fitz began to change as he was enthralled by Lorelei, whose power only affected men. She discussed with Skye how men are flawed.

HYDRA Uprising
"At least we still have each other." "Good, 'cause the last thing I want is for things to change." "Fitz...It's too late for that."

- Simmons and Leo Fitz

After Deathlok critically injured Felix Blake, Simmons was transferred to the Hub to be a consultant on Deathlok. She was enthusiastic because the Hub had better equipment than the Bus for analyzing Skye's and Phil Coulson's blood to reproduce the drug. Triplett was ordered to be her escort. Simmons called Anne Weaver for assistance, but she had her own problems: HYDRA was taking over the S.H.I.E.L.D. Academy. Weaver warned Simmons that the civil war had begun. Simmons found herself locked in a room with Triplett, but he quelled her fears by giving her his pocket knife. When Victoria Hand's agents found them, they passed her test of loyalty to S.H.I.E.L.D. When Coulson's loyalty was questioned, Simmons argued with Hand until she had his "crimes" listed. Ultimately, Simmons was reunited with the team and Tripett impressed her with his strength and loyalty.

When the team was forced to leave the Hub and Simmons had to relinquish her badge, she cried. Coulson ordered an evacuation in order to stay ahead of Colonel Glenn Talbot. She vouched for Triplett's loyalty and place on the team. During their trip to Providence, Fitz approached her, and she let him know that things were no longer the same.

Betrayed
When the team arrived at Providence they were greeted by Agent Eric Koenig who showed them around the base; he also told the team that Nick Fury had indeed been killed during HYDRA's attack on S.H.I.E.L.D. Agent Grant Ward joined the team later badly injured. Simmons performed first aid on his wounds and Ward claimed that the Fridge was overrun by HYDRA and he had killed John Garrett in the fight. When Agent Eric Koenig asked Simmons why she was there during her Lie Detector test, Simmons said she did not know. She went with Phil Coulson, Antoine Triplett and Leo Fitz to Portland to apprehend Blackout, and learned of Coulson's past with Audrey Nathan. After defeating the Fridge escapee and saving Audrey Nathan, the splinter team returned to find the Bus and the others gone. Simmons decided to make pancakes, while Coulson tried to find the others. She found Koenig's body in a closet while Fitz found a message from Skye, "Ward is HYDRA." Simmons gave Koenig's autopsy report proving Grant Ward killed him. Then Maria Hill led Colonel Glenn Talbot to Providence. Simmons debated with Talbot but it took Coulson and Hill to begin the escape. Ultimately, Simmons and the team were reunited in a hotel in Los Angeles.

The next morning, while watching the news, Simmons wondered why Deathlok killed Alejandro Castillo. Coulson and the team went to Palo Alto to infiltrate the Cybertek Corporate Headquarters there to find Deathlok and eventually John Garrett. The team learned that Garrett was in Cuba and went there. While Simmons was spying on the Centipede Project with Fitz, Grant Ward captured them and took them aboard the Bus. Fitz activated an EMP Joy Buzzer that fatally wounded Garrett, but as the two tried to hide in a Medical Pod, Ward cornered them and ejected them off the Bus into the Atlantic Ocean.

Best Friends Forever
When Simmons awakened, she saw Leo Fitz with a sling over his broken arm, feeling hopeless. He explained that the Medical Pod they were in sank ninety feet and he tried to send a signal but, with S.H.I.E.L.D. dissolved, he doubts that anyone received it. Determined not to die, Simmons created a plan to break the glass without the water pressure crushing them. Fitz gave her the only air device and decided to stay behind as he told her how he truly felt about her. Simmons cried and allowed him to trigger the release, but she did not allow him to die. She swam to the surface with him and was saved by Nick Fury, who received the distress call.

In a Hyperbaric Chamber, Simmons and Fury discussed how to find Phil Coulson and Fitz's condition. After the battle at Cybertek, Simmons was reunited with the team as Coulson became the Director of S.H.I.E.L.D. and they met Billy Koenig in the Playground. When asked about Fitz, Simmons only stated that he was alive.

Undercover
"Have you made friends?" "Oh, sir, you don't need to worry. I mean, it's been a tad lonely, true, but you weren't asking out of concern of my feelings, were you?" "Undercover is all about the relationships you make. If you're gonna move up in HYDRA, you need to make friends."

- Phil Coulson and Jemma Simmons

A few months after the ordeal, Director Phil Coulson put Simmons on a top-secret assignment in which she was to infiltrate HYDRA at its deepest levels. Moving to a house at 1180 N. Mearne Drive in Crosswell, Delaware, she joined the science division and began working at the HYDRA Laboratories. She slowly caught the attention of prominent HYDRA officer Sunil Bakshi. To see if he could trust her, he sent Simmons onto a freighter harboring the dangerous Donnie Gill. She proved her trustworthiness and remained undercover. Her actions made Bakshi promote her, telling Daniel Whitehall that if something were to happen, they could always brainwash her.

While Simmons was out on her secret assignment, Fitz became withdrawn and unfocused in her absence. His mental downward spiral went so far as to him speaking to a hallucination of Simmons, believing that she was still there helping him. Coulson neglected to share Fitz's deteriorating condition with Simmons, believing that knowledge of it would jeopardize her otherwise important mission. He, however, did allow Simmons to receive a video of the others wishing her a happy birthday and Fitz's message to her saying for her to greet her parents for him. Mislead, Fitz felt Simmons left him because she does not return his affection. He told Alphonso Mackenzie and Lance Hunter his feelings as they celebrated surviving a mission in Florida. Weeks later, Simmons had an adjacent desk with her supervisor Kenneth Turgeon. They were ordered by Sunil Bakshi to attend a meeting that Daniel Whitehall was having with his top scientists, including Dr. Lingenfelter. Lingenfelter attempted to duplicate the effects of the Obelisk from skin samples of one of its victims, a waitress, but the experiment at the wedding of Pete and Mariah Leitner did not meet Whitehall's expectations. Whitehall asked Simmons for her expert opinion, to Turgeon's jealousy. Simmons assured him that the Obelisk could be made into a weapon of mass destruction.

Simmons then sent S.H.I.E.L.D. a message via Flex Screen, not knowing that Raina was watching her.

Bobbi Morse, head of security, and Bakshi realized that there was a mole in the facility and searched everyone's desk. As Morse interrogated Simmons, Turgeon was dragged away, as a flex screen was found in his desk.

Later, when Simmons exited the restroom, all eyes were on her; Raina had sent a file transfer blowing her cover. Bakshi sent a security team after her and Simmons ran. When Morse came with her team, Simmons was trapped until Morse used her battle staves to fight the guards, since she was also an undercover S.H.I.E.L.D. agent. The two jumped from the roof where a cloaked Quinjet piloted by Antoine Triplett awaited them.

At the Playground, Leo Fitz greeted Simmons with hesitancy.

Reunion with Fitz
"I'm not trying to treat you any differently than-" "I know, but I am different and I'm trying not to be, but I am!"

- Jemma Simmons and Leo Fitz

Simmons noted that Grant Ward had no way of knowing the time, but every morning at 5:30 he awakened and exercised. Skye asked her how she knew that; Simmons was stationed to watch Ward before she went undercover. Their conversation was interrupted by Melinda May alerting them that the United Nations was attacked.

When Simmons saw that those hit during HYDRA's attack on the United Nations Headquarters were disintegrated, she helped identify Toshiro Mori from the hard drive that was obtained from HYDRA Laboratories. Coulson asked her to learn more from the hard drive.

Going to Fitz for help in accessing the hard drive, the two started arguing about why Simmons left. She could not handle the conversation and left Fitz to his work. Alphonso Mackenzie assisted Fitz, and when Simmons returned, they told her that the Splinter Bombs were created by Vincent Beckers.

When Ward, being transferred to federal custody, went by her, Simmons promised to kill him if they ever met again.

Simmons went to the garage to thank Mackenzie for his help and his friendship with Fitz. Mackenzie told her that Fitz was better without her; she tearfully agreed.

Helping Coulson's Problems
Simmons berated Alphonso Mackenzie for his words of bravado when he and Leo Fitz brought the body of Janice Robbins to her so she could perform an autopsy. She learned that the knife cuts on her did not kill her but the trauma and pain did.

She accompanied Skye and Phil Coulson to the secret room holding the Theta Brain-Wave Frequency Machine; Coulson wanted to remember the past pertaining to Project T.A.H.I.T.I. and his and Robbins' connection to it. Simmons reminded Coulson that, after six months of research, she and Fitz still did not fully understand the machine. Coulson proceeded nonetheless and Simmons was stationed to watch his vitals as he recalled the past. When Coulson could no longer handle the experience, Simmons ordered the session to end.

Afterwards, Simmons wondered where Skye went and asked Alphonso Mackenzie and Fitz who were playing video games. Simmons saw on the video monitor to Vault D Skye waving to the camera; Coulson locked her inside with the Inertial Confinement Laser Barrier and left. Simmons freed Skye, who went to chase the Director.

Later, Simmons was among the assembled senior agents when Director Coulson gave the new mission: find the city that matched the City Blueprints before HYDRA can.

Familiar Face
"Did you hear what I said? Peggy Carter, founder, happens to be British, held this in her hand."

- Jemma Simmons

As Bobbi Morse interrogated Sunil Bakshi, Simmons showed her admiration for her being that close to him. Simmons suggested to Melinda May that they procure old Strategic Scientific Reserve files to find what connection Daniel Whitehall had to the Red Skull, causing May to open Vault B. Simmons loved that she was touching the same files as her hero and S.H.I.E.L.D. founder Peggy Carter. When she saw the picture of Werner Reinhardt, Simmons realized that he was Whitehall; however, her research could not find the secret of Reinhardt's youth.

Science Team Leader
Simmons inspected Antoine Triplett's wounds when he returned to the Playground from Australia and told him that she was thankful that he survived his mission. Before Triplett could tell her about Calvin Zabo, Skye's father, Skye interrupted and the three discussed him together. Simmons was chosen to accompany Phil Coulson to Puerto Rico to destroy the city that matched the City Blueprints. While preparing for the trip, she shared with Bobbi Morse her feelings about Leo Fitz, the coma he experienced, and how she was not ready for a relationship with him greater than friendship. Upon arrival, the silence between the two scientists caused Mack to leave them alone to talk privately. Tearfully, Simmons attempted to explain to Fitz why she left him to go undercover months ago; Fitz interrupted her to say that he could not work with her. She misinterpreted his statement and asked if he was quitting S.H.I.E.L.D.; Fitz felt it best that he work for her, making her leader of the science team.

Inside Castillo San Cristóbal, Simmons and Fitz prepared the D.W.A.R.F.s to test the structural integrity of the city so when they destroyed it, it would not affect the residents of San Juan. When the drones lost power, Mackenzie was sent into the hundred foot shaft to investigate. Hearing his screams, he was hoisted up; Mackenzie then slapped Coulson across the room. During the battle, Simmons was hit and began to fall into the hole. Coulson, ordering Fitz to shoot the super-strong mechanic, grabbed Simmons and struggled to stop her fall. As Mackenzie approached Simmons and Coulson, Morse used her battle staves to electrocute him; stunned, he fell into the hundred foot hole just as Coulson saved Simmons. Simmons, along with Fitz and Antoine Triplett, in containment suits, then went down to the Kree City to plant explosives and to see if Mackenzie survived. They witnessed Triplett return to the city to defuse the bombs when he learned that Skye and Phil Coulson entered. An earthquake occurred as she waited with Fitz and they hugged in panic as the island shook.

Changing Opinions
Simmons was in charge of a team of scientists mapping the Kree City. Her teams planned to document, then flood, the area so neither HYDRA nor any one else could harness it. When her team found the remains of Antoine Triplett, she shouted for them to handle it carefully. However, two scientists were dragged off and killed by a transformed Raina. Simmons shot at Raina and managed to hit her several times; however, Raina still escaped up a lift. Simmons reported this to Phil Coulson who allowed her to return to the Playground, since Simmons wanted to check on Skye.

Back at the Playground, Simmons told Skye who was in quarantine about her encounter with Raina. She showed her that Raina's genetic makeup had changed and said that aliens should be neutralised to prevent an epidemic. When Skye pointed out the harshness of her stated conclusion, Simmons told Skye that everything was her fault, including the death of Triplett, because of her interest in superpowers. She decided that instead of her dedicating half of her life trying to understand alien technology and biology, she should have been focused on trying to exterminate it. Skye tried to refute her claim pointing out that she had helped plenty people with powers; Simmons pointed out the hostile ones like Donnie Gill, Chan Ho Yin, and Carl Creel. Simmons even noted that the Avengers themselves would not be necessary if they did not unleash an alien invasion on the world. As Melinda May and Coulson wondered what to do about Raina, Simmons voiced that killing Raina would not be the worst scenario.

Simmons returned to Skye's cell when Leo Fitz brought her blood test results; the test said that Skye was normal. Unknown to Simmons, Fitz gave false results to quiet Simmons' possible fear of her until everyone would be more receptive of her change.

Simmons and the other senior agents then sat remembering Triplett with Skye pointing out they would laugh a lot less with him gone.

Leo Fitz's Lie
Simmons later came across the real results of Skye's blood test on Fitz's computer, and noticed how extraordinary they were. Fitz told her that the data was simply a simulation he had done. She was amazed at the accuracy, but believed him.

Simmons realized that Fitz had lied to her about the blood test results when Skye's powers began firing out of control. She was deeply hurt, and told him so. She told him that the first time she had ever lied to him was when she went undercover for HYDRA.

Doctor Andrew Garner came aboard the Bus to work with Skye, and Fitz and Simmons briefly discussed May and Garner. For a moment, their relationship seemed to improve, but Simmons soon began ignoring Fitz again.

Simmons made it quite clear that she intended to help suppress Skye's powers instead of harnessing them, as Fitz wanted to do. She constructed a pair of gloves intended to absorb the shock of Skye's powers, therefore harming the latter less when she redirected them inside. She refused to specify when Fitz asked her what was in the case that she had taken to Coulson, because the gloves were the content.

Tricking Bobbi Morse
"Coulson, May, I've got her."

- Jemma Simmons

Simmons was alone during the blackout in the Playground until Bobbi Morse found her in the locker area. Simmons knew of Morse's true loyalty, and was therefore scared at first. She was able to calm herself, and act as though she was oblivious to the true unfolding events. She managed to stall Morse, tricking her into holding two small devices that shocked and rendered her unconscious.

When S.H.I.E.L.D. agents loyal to Robert Gonzales invaded the Playground, Simmons and Leo Fitz sat side by side on the floor, watching the events around them, unable to do anything. Simmons knew Fitz was scared, so she rested her hand on top of his, and he returned the gesture. Anne Weaver asked Simmons for her medical expertise on Alphonso Mackenzie; she first looked at Fitz and waited for his approval before going to attend to Mackenzie.

The Switch
"You should have brought cupcakes."

- Jemma Simmons to Robert Gonzales

Simmons and Fitz discussed the Toolbox before being confronted by Robert Gonzales and Bobbi Morse. Gonzales attempted to exchange pleasantries, but Simmons rebuffed him. Gonzales asked Leo Fitz to open the Toolbox, and Simmons retaliated with asking what would happen to him if he refused. When Morse assured them that Fitz would be free to go, he left to pack his bags, leaving Simmons.

Simmons and Morse talked while Fitz was packing, and Morse seemingly convinced Simmons to stay and help to open the Toolbox. Instead, Simmons replicated the box in order to smuggle it out of the Playground with Fitz. When Fitz learned what she was doing, he covered her actions and convinced Alphonso Mackenzie and Morse that Simmons was in earnest.

She later packed Fitz's favorite sandwich in his bag, and helped him get the backpack on. She watched with Morse and Mackenzie as Fitz left the base.

Discoveries
When Melinda May returned to the Playground, Simmons greeted her warmly. May asked her to assist her in recent revelations that Phil Coulson was accused of being deceptive. May told Simmons that Coulson asked her to work on upgrades to Deathlok without her knowledge; they decided to learn what Theta Protocol was.

Simmons learned that Coulson was spending a lot of money and was having clandestine meetings with Andrew Garner. Alphonso Mackenzie theorized that Coulson was making a super-powered team without anyone's knowledge. May ordered Simmons to open the Toolbox, but Simmons hesitated, not wanting to reveal that she had duplicated it and smuggled the real one out of the Playground with Leo Fitz. However, she told May that she would do her best.

Finding Coulson
When Simmons and Melinda May were in Coulson's office, Simmons revealed that she had worked on a fake Toolbox and that had she helped Leo Fitz in smuggling out the real one. May told her that she would handle it. Simmons continued her false attempts to open the Toolbox as May and Bobbi Morse entered the lab, but May told her she could stop because she had told Morse the truth. May and Morse asked her if she could hack into Deathlok's hard-drive so they could have an opportunity to see, through him, where Coulson was. Simmons said it should not be too hard and dumped the fake Toolbox in the trash.

While Simmons worked on her mission, May came to ask her if there was any luck. Simmons argued with her that she was on Robert Gonzales's side, but May said that she the only reason why she helped him was because of Phil Coulson's lies. Simmons told her she didn't care of what was inside the Toolbox but the only thing she knew was that Coulson was just trying to protect Skye. Simmons, May, Morse and Alphonso Mackenzie were in Coulson's office when Skye called abruptly and said she was with Calvin Zabo and S.H.I.E.L.D. needed to take him from where she was. May signaled Simmons to locate Skye's location.

Later, Simmons succeeded hacking Deathlok's hard-drive. She and May were shocked after they saw that Coulson was with Grant Ward.

Attack on the Arctic HYDRA Research Facility
"Go on, get it over with you monster." "You really have changed, Simmons... I'm disappointed in you."

- Jemma Simmons and Grant Ward

Phil Coulson returned to the Playground with Leo Fitz, Grant Ward and Agent 33, and Fitz went to see Simmons. They talked together about Ward and Agent 33. Simmons did not understand how Coulson worked together with Ward, so she explained to Fitz how she could kill Ward with a Splinter Bomb. Fitz realized that she was serious about the idea, but Simmons said she was only arming herself against Ward. Knowing she had an opportunity to kill Ward and get revenge on him, Simmons asked Coulson if she could join the mission to infiltrate the Arctic HYDRA Research Facility and rescue Deathlok. Coulson agreed she could come to look after Peterson's injuries. Simmons and the team, which included Coulson, Melinda May, Fitz, and Ward, boarded the Bus. They heard a loud noise but it was revealed it had been Skye, who had been teleported to assist them with the mission and to rescue her friend, Lincoln Campbell.

On their way to the base, Simmons and Fitz talked with Skye about the place she had been. Coulson asked Ward to give the information about the base sent by Sunil Bakshi, who Ward had brainwashed into serving him. Ward began, but then started to explain his actions during the time it had been revealed he was a HYDRA agent. Ward asked for the team's forgiveness, but nobody gave it. Near the base, HYDRA spotted the Bus' location and sent missiles to shoot it down, but the team escaped with a Quinjet and entered the base. In the base, the team joined Sunil Bakshi and they were split into two groups: Coulson, May and Fitz went to take down the defense system so Robert Gonzales' men could destroy the base, while Simmons, Skye, Ward, and Bakshi went to find Peterson and Campbell. Bakshi led them to a room where Peterson was, but HYDRA agents shot in their direction. Skye used her powers to knock them out and they found Peterson in his cell with Peterson unable to stand due to the torture he had endured. While Skye looked for Campbell, Simmons asked Ward to find something with which she could take Peterson, in order to make a distraction and kill Ward with a Splinter Bomb.

While Grant Ward had his back turned and was distracted searching the base, Simmons sneaked into the room and prepared to kill him with the bomb; however when she threw the bomb, Sunil Bakshi sacrificed his own life for Ward's, jumping in front of him and having his body turned to dust within seconds. Simmons watched as Ward pulled his gun and aimed it at her, demanding to know why she had tried to kill her. Instead of shooting her, he lectured her and told her that he was disappointed in the change in her. He then allowed her to live and left the base. With Ward gone, Simmons went to help Skye rescue Campbell and Peterson before Robert Gonzales destroyed the base.

With the base was destroyed, Simmons and the team returned to the Playground. Simmons and Fitz talked with Peterson about repairing his leg, which had been removed and destroyed by Doctor List and his HYDRA scientists. Peterson asked what happened to Sunil Bakshi, and Simmons said he did not make it, giving no details and choosing not to reveal the truth about her attempt to assassinate Grant Ward.

At the Playground
Simmons and Leo Fitz watched Skye while she was near the anesthetized Lincoln Campbell. Then, they informed Kara Palamas that the brainwashing of HYDRA was not affecting her reactions anymore. Palamas thanked them and asked Simmons about her undercover mission in HYDRA with Bobbi Morse, but before Simmons could explain more, the light of the building turned on and off, as Campbell awoke from his coma. Simmons checked if everything was alright, and put Campbell on the Index. She came to say goodbye to Skye before she left with Campbell to their home.

Ambush in Afterlife
S.H.I.E.L.D. located the Inhumans' base and set them as a threat, and Simmons' role in S.H.I.E.L.D.'s delegation to their base was putting all of the Inhumans on the Index. Before she went to there, she talked with Fitz about her attempt to kill Grant Ward and that the next horrible thing he will do, would be on her. Near the base, Simmons were in a Quinjet and informed Robert Gonzales that there are more people in there than they had expected. After they landed, Gonzales went to meet the Inhumans' leader and Skye's mother, Jiaying, and Simmons was with Skye and Campbell. But soon after, they heard gunfire from the room where Gonzales and Jiaying were. They ran to the noise, where they found Jiaying bleeding, claiming Gonzales had shot her. Simmons tried to help, but was rebuffed by the Inhumans and told to go back to S.H.I.E.L.D.

Open War
"None of this would've happened if Gonzales hadn't attacked." "You can't actually believe he would do something like this." "Oh no, Gonzales would never attack a base unprovoked."

- Jemma Simmons and Anne Weaver

Simmons came to a Quinjet and told Melinda May and Phil Coulson what happened. Coulson asked her where was Robert Gonzales now, but Simmons did not know, so May went to search for him. After May was knocked out by Skye, the Quinjet that she and Simmons were in returned to the Playground. On their way to the base, Coulson asked Simmons if they had confirmation on who had fired the missile within Afterlife, but Simmons said they had not and they were still searching for the that Quinjet. May woke up and Simmons asked how she felt and then blamed Robert Gonzales that his action led to this conflict, but Anne Weaver defended Gonzales, saying that he would not do such a thing because he had wanted to give Jiaying a peace offering. Simmons did not understood Jiaying's move, asking why she invited S.H.I.E.L.D. only to attack them. Coulson did not know why but postulated that Calvin Zabo might.

Calvin Zabo's Transformation
"Tell me you figured out what drugs Cal took, because my gut's saying everything ever made." "I haven't fully sequenced the formula yet, if only for the multitude of trace drugs found."

- Phil Coulson and Jemma Simmons

As they returned to the Playground with Calvin Zabo, Simmons said to Phil Coulson that she feared that Zabo was a Trojan horse and that he had taken a formula from the vials. She said to him she was going to analyze it in the lab. In Coulson's office, Coulson discovered that Jiaying staged the attack of S.H.I.E.L.D. on Afterlife so the Inhumans would think that they declared war on them, a ploy that deceived even Skye.

Coulson came to check Simmons' progress with analyzing the formula and Simmons gave him a partial list of the chemicals in the formula, saying Zabo made an unsuccessful attempt to get super strength. Coulson asked if he would be alright but Simmons said he had taken three vials so he should be dead. After Zabo had a heart attack, Simmons tried to revive him by giving him an adrenaline syringe. Zabo's heart went back to work but he became monstrous with remarkable strength. Simmons, Coulson and Leo Fitz tried to shoot him with I.C.E.R.s, but they were ineffective. Coulson ordered them to go so he could talk with him. A short time after, when Zabo walked around the base, Simmons and Fitz lured him into the hangar where Coulson could reason with him.

Confession
"It means a lot to me that we are friends again, and I... Maybe when you get back, we can finally just talk about it." "It's... There is nothing to discuss, Jemma." "Maybe there is."

- Jemma Simmons and Leo Fitz

Phil Coulson convinced Calvin Zabo to assist them against Jiaying, and Zabo was put under armed guard while Simmons helped counteract the effects of his formula, resulting in the reverse of his physical changes. Leo Fitz then informed Coulson that the Inhumans had hijacked the Iliad while they were fighting Zabo.

Later, Melinda May and Lance Hunter found Bobbi Morse seriously injured. The two flew her to the Playground where Simmons prepared to analyze Morse in an alternate room. Coulson and Fitz came and asked about Morse's condition on her way there. Simmons responded that she barely survived, and Coulson asked if Zabo was stable enough to join them in the mission to retake the Iliad, but Simmons and Fitz were surprised to hear that. May and Hunter then entered the room with the wounded Morse. Simmons and her team of physicians started to operate on her.

Finished with the operation, and with Morse beginning to recover, Simmons put her hand on Hunter's shoulder to comfort him. She then came to say goodbye to Fitz, who was in a expedition of S.H.I.E.L.D. to retake the Iliad. She said to him to be careful but Fitz said that he will just get the job done. Simmons admitted that seeing Hunter with Morse made her realize that they had never spoken about what Fitz said to her in the bottom of the ocean. Fitz was surprised she wanted to speak about it now, but Simmons said hesitatingly that it meant a lot to her that they were friends again and they could talk about it. Fitz said that that there was nothing to discuss but Simmons replied that maybe there was. Coulson then entered and said to Fitz that they were on the move. After Fitz walked out, Simmons started crying.

Monolith
"You know we could get better readings if we dropped a probe into the glass enclosure." "We're never opening that damn box in a thousand years."

- Jemma Simmons and Alphonso Mackenzie

S.H.I.E.L.D. and Skye were able to stop Jiaying's plans, leading to the deaths of Jiaying and the teleporter Gordon. A few days later, Phil Coulson appointed Alphonso Mackenzie to the head of the alien artifacts division. Simmons worked with Anne Weaver on the Monolith on the Iliad. She said that they could get better data if they could put a probe inside the glass which protected the stone. Mackenzie then responded that they would not open the glass for thousands of years. While continuing to work on the stone, Leo Fitz awkwardly tried to ask Simmons out to dinner, however it took her a long time to realise he meant they go out together on a date. As Fitz became more awkward he stumbled, causing the lock on the case to loosen. Simmons agreed to join him and he nervously left the room. Once he had gone, Simmons then found out that the case was unlocked; while trying to re-lock the case, the stone morphed into its liquid form, shooting out and swallowing her. Simmons shouted, and then the stone went back to its original solid form.

Other Worldly Experience
"There has to be a sunrise, eventually."

- Jemma Simmons

Finding herself on another planet, Simmons waited for hours for someone to find her and extract her. After twenty-two hours, she noted that the sun had not risen. Simmons kept herself grounded by talking to a picture of Leo Fitz on her cell phone; as she made markers from stones showing the direction she was going, Simmons talked to herself about the date they had planned. Realizing that a normal human can live without water for one hundred hours, Simmons sought water; she found it after one hundred and one.

At one hundred nine hours, Simmons swam through the water, finally finding time to relax. Suddenly, she was grabbed by a plant in the water and almost drowned; Simmons fought it and detached a tentacle. After eating it, she decided that she would grow weak if she did not continue to have food. Simmons returned to the pond and killed the creature cooking and eating it while continuing to look at the image of Fitz on her phone.

Meeting Will Daniels
To be added

New Experiments
To be added

Trapped on Another World
While her fellow agents were left clueless as to what became of Simmons, the Monolith had actually transported her across the galaxy. Stranded on a desolate alien planet with two moons, Simmons was forced to survive alone for over four months. As she trekked across the wide dark landscape, she soon found herself being pursued by a mysterious force. During the chase, she received a head wound, which she treated by applying dirt to it while hiding and wishing that someone would find a way to bring her home.

Fleeing "Death"
To be added

Rescued
"Fitz..."

- Jemma Simmons

Due to research into the stars conducted by Simmons, she and Will Daniels were able to determine when the sun was due to rise over the planet, the first sunrise in eighteen years. The pair shared a kiss as they stepped outside and waited to see for the sun for the first time in over a decade. Suddenly Simmons spotted a flair being fired in the distance and determined it must be Leo Fitz finally having found her. Simmons ran across the desert with Daniels as they tried to find the source of the flair, but became separated as a sandstorm appeared. Simmons spotted what appeared to be a NASA astronaut and called out to Daniels that his team had found him, but Daniels warned her that it could only be the deadly being on the planet trying to trick her mind. Daniels ordered Simmons to run as he drew his gun and engaged the creature, firing his only bullet at It while Simmons followed the sound of Leo Fitz's voice.

She moved towards the light and encountered Fitz, who had thrown himself into the activated portal to find her. Crawling to him as the sandstorm worsened, she tried to reach him, only for him to be pulled away from her as the rope he was attached to began to take him back. Refusing to give up, Simmons dragged herself back towards Fitz, and they both grabbed hold of each other's hands and made it back through the portal before it exploded. Safe in the English castle, Simmons hugged Fitz as Phil Coulson, Bobbi Morse, Elliot Randolph, and Alphonso Mackenzie stared at them. Coulson and Morse ran tests on Simmons and determined that she was not infected or contagious and everything was normal despite her many months on a distant planet they knew nothing about. Suddenly, Simmons awakened from a nightmare and she held a piece of metal shaped like a shiv in a defensive position. She regained her senses and looked around; she found herself in a Medical Pod with Fitz in a chair, sleeping next to her bed. Simmons laid her head near his lap and returned to sleep, comforted by his presence.

Return to the Real World
"She said she was being hunted." "Wait. What? What does that mean? Hunted by what?" "She didn't say. I don't know if she even knows."

- Leo Fitz and Alphonso Mackenzie

A team checked her physical condition and determined that her body adapted to living on the other planet. Simmons took a bath and washed the filth on her body. Leo Fitz accompanied her in every step she made since she was still getting used to Earth's lower gravity. They walked to the lab where Bobbi Morse greeted her. Fitz theorized that if she saw the lab again, she would feel better. Suddenly, Morse's phone rang, but Simmons heard it very loud. Simmons sent her regards to Lance Hunter, who called Morse to update her on his campaign to kill Grant Ward. Simmons then told Fitz that she did not want to be there as there were too many distractions. Even a small divisive sounded very loud to her, so Fitz took her to her room.

In her room, Simmons was visited by Daisy Johnson; at first, Simmons called her "Skye" but she corrected herself. Johnson said to her that she would be with her any time when she would want to talk about what happened to her. Simmons said that she would rather listen about the Inhuman Outbreak. Suddenly, Johnson got a call which alarmed her; Simmons said she could answer it.

Dinner Date
Fitz took Simmons to a restaurant as he had promised to her months ago. When Simmons asked him where were all the other people, he said that he made sure there would not be any distractions. After they sat, Simmons said that she did not know how to thank him enough for what he had done for her. Fitz said that she did not have to say anything. Fitz then suggested to drink the wine, but it reminded her of how she and Will Daniels drank the old wine. She started to cry, so Fitz sat next to her and comforted her.

Return to Danger
"I have to go back."

- Jemma Simmons to Bobbi Morse Simmons knew that she had to find a way to open the portal again to save Will Daniels's life. She examined the Monolith remains in the lab. But when Bobbi Morse came and assured her that it will not open again, Simmons said that it had to and she must go back to the planet.

Simmons researched the fragments of the Monolith and wrote her findings in a notebook. While researching Lash, Leo Fitz found the notebook and asked Morse what it was. Suddenly, Simmons entered the laboratory and grabbed the notebook from Fitz; the papers fell to the floor and were scattered. Simmons became upset and told Fitz to leave her things alone before storming off. Fitz was left perplexed.

Simmons went to see Morse after Morse finished her rehabilitation regiment and apologized for accusing her of betraying their secret to Fitz. Morse thought nothing of it, but confided to Simmons that she believed that Lance Hunter was in danger. Later, Simmons was in her room reorganizing the notebook when Fitz entered, wanting to know what was happening. Simmons realized that she could not rescue Daniels without assistance.

Telling Fitz About Will
Simmons told Leo Fitz about her experience on Maveth and the relationship that she had with Will Daniels. For a moment, Fitz would not talk to her and she began to cry. Collecting herself, Simmons chased after Fitz, begging him to understand; Fitz said that he did understand and showed her his computer screen, revealing the research he had done over the past six months on her location. Fitz declared that they will save Daniels; Simmons smiled.

Awaiting Results
Simmons sat across from Andrew Garner reminding him of his words as she played psychologist; Garner confessed to her that he disliked how others were treating him since he was injured in an assassination attempt. Simmons told him that others underestimate how strong smart people truly are.

She then received a phone call from Daisy Johnson who had a blood sample from Luther Banks that she wanted tested to determine if he could be an Inhuman. Simmons took the assignment and ran the test.

Simmons entered the workplace of Leo Fitz and told Johnson that Banks was not an Inhuman; meanwhile, Fitz was finishing his technical support for Melinda May. Simmons asked Fitz how the research he was doing into the Monolith was progressing. He could only tell her that the computer simulations had not yet found a way to open a viable portal. Simmons then told Fitz that if he knew Will Daniels, then he would understand why she desperately hopes to rescue him; Fitz assured her that he will get to know Daniels. Unknown to Simmons, Fitz was researching Daniels' background.

Watching the Sunrise
Simmons gave her phone to Leo Fitz and hoped that he could repair it; she told him that she made logs on it during her time on Maveth and that she thought he could use that information to find a way to open a portal. Fitz took the phone and said he would do the research. Later, Simmons searched the Playground for an eastern window so she could watch the sun rise. Fitz found her and told her that he was taking a break. He then questioned her about her thought processes and state of mind as she recorded her logs. Simmons, knowing that Fitz was referring to her affirmations of love to him and her said desire to start a family with him, told Fitz that she had perfect clarity when she made her logs. The two then watched as the morning began.

Discovering an Unlikely Connection
"I can't fathom any way out of this without hurting someone I care about."

- Jemma Simmons To be added

Personality
"You're a surprisingly bad liar, Agent Simmons." "I know, but I'm getting better at it."

- Antoine Triplett and Jemma Simmons

Jemma Simmons is known as the attractive nerd and also a science buff on her profile for S.H.I.E.L.D. She has a normally calm and rational attitude, often relying on what is or isn't scientific fact. She is very forgiving, as seen when she so quickly forgave Skye after she betrayed them with the Rising Tide. However, she did not forgive Grant Ward for his betrayal of the team.

She has a deep affection towards Leo Fitz, refusing to let him sacrifice his life for her. Recently, she has found being around Fitz hard because of the memories she has of the man he was before his brain was damaged.

Simmons was a terrible liar, proved many times over, prominently the instance in the Hub when she shot Agent Jasper Sitwell with the Night-Night Gun out of panic when he did not believe her lies. However, Simmons has improved on this flaw during her undercover assignment in HYDRA's science division. Simmons also has a bright outlook on life, most often trying to see the best in any situation, and then trying to make them better.

The death of Antoine Triplett drastically changed Simmons' views of superpowers and alien artifacts. She thought that the world was a better place without anyone with powers, to the point in almost saying that killing Raina, since she had powers, was the best option for the team. She viewed Skye as being equal to Hulk in terms of destructive capability and lack of control; Simmons hoped to find a way to remove her powers permanently, or at least supress them through sedatives. Her change of opinions was so surprising that Fitz himself said that her change in personality is almost scary. This change also brought out a darker side of Simmons' personality as she intended to kill Grant Ward with a Splinter Bomb after all of his betrayals and while she failed due to Sunil Bakshi's interference, she calmly told them that he didn't make it, not revealing his death was caused by her murder attempt.

Simmons has an attraction to men who act heroic, especially in regards to saving her. She was attracted to Ward after he saved her life when she attempted suicide; her closeness to Triplett grew when he defended her against Victoria Hand and her deceptive loyalty test. Simmons began an affair with Will Daniels after she lost hope that Fitz, the man who constantly risks his well-being on her behalf, would save her. However, Fitz did save her, causing a conundrum for her emotionally.

Abilities
"You're a real miracle worker."

- Antoine Triplett

"You're not a very good liar, are you?"
 * Genius Level Intellect: Simmons possessed two PhDs' for biochemistry by the time she was 17, and continued her studies at the S.H.I.E.L.D. Academy of Science and Technology. She graduated as one of the youngest cadets in the history of the Academy due to her intellect. Simmons possesses a sharp and bright mind, focused on analysis, that has allowed her to research and develop many breakthrough equipment for S.H.I.E.L.D.
 * Master Scientist: Simmons' expertise in the field of biochemistry has allowed her to work in the research and development of many breakthrough discoveries, such as the use of dentrotoxin as a tranquilizer ammunition, the cure for a virus of extraterrestrial origin, a crystalline nucleation process capable of turning moisture into ice or an odorless scent used for tracking. She is highly gifted and knowledgeable in many fields of science practiced such as biology, biochemistry, anatomy and physics.
 * Expert Physician: Simmons was often charged with evaluating and treating any injuries sustained by her teammates and colleagues, being skilled enough to apply advanced first aid to Skye when she was shot by Ian Quinn, and to perform an autopsy on Eric Koenig's corpse. She has extensive knowledge of human, animal and alien physiology, anatomy and DNA when needed even beating out scientists, physicians and terroristic agencies ahead of time.

- Bobbi Morse to Jemma Simmons


 * Spy: Originally, Coulson did not trust Simmons as a spy, considering her lying skills were subpar; he had Simmons give support to Melinda May when she went undercover into Cybertek Corporate Headquarters. As Simmons learned to lie better, Coulson sent her to HYDRA Laboratories to gain information on the organization's schemes, operations and research managing to fool her direct co-workers and even Sunil Bakshi. Over time, she learnt to use her apparent naivety as a tool, even tricking Bobbi Morse while the Playground was under attack.
 * Marksman: Simmons was able to handle a gun with ease when she mistook Phil Coulson for an intruder in her apartment while on her undercover assignment within HYDRA. She hit Raina multiple times when Raina attacked scientists under Simmons' charge.

Weapons

 * : The Smith & Wesson M&P pistol is the standard sidearm carried by S.H.I.E.L.D. agents, and, as such, Simmons was issued with one of these to protect herself when examining the remains of the Kree City under Puerto Rico. She used it to shoot at Raina, but she managed to withstand the bullets. Simmons also took it to hold and unconscious Bobbi Morse when it was revealed that she had infiltrated the Playground as a member of the S.H.I.E.L.D. faction led by Robert Gonzales.
 * : Simmons carried one of these guns during her undercover assignment within HYDRA, and grabbed it when she mistook Phil Coulson for an intruder in her apartment.
 * Night-Night Pistol: Simmons helped Leo Fitz on the design of the original Night-Night Gun, by creating the dendrotoxin rounds used as ammunition, and began to carry one of the pistols in her purse. She accidentally used it to shoot Jasper Sitwell when she was in a restricted area of the Hub, and then again during the mission in a train through Italy, shooting at her teammates as she regained consciousness from being affected by a Dendrotoxin Grenade.
 * Splinter Bomb: Simmons kept a case of the Splinters Bombs that HYDRA developed as a means of weaponizing the effects of the Diviner, and took one with her during a rescue mission to a HYDRA base in the Arctic, hoping to use it to kill Grant Ward. She tried to ambush Ward, but Sunil Bakshi, who was working for him, attacked Simmons and ended up being killed by the Splinter Bomb.

Other Equipment

 * D.W.A.R.F.s; Simmons often used the D.W.A.R.F.s in order to analyze and retrieve forensic data during his field missions, such as in the Centipede laboratory in Los Angeles, the temple where an 0-8-4 was located in Peru or the barn where Frank Whalen's corpse was found floating,
 * Full-Spectrum Goggles: A set of goggles designed by her partner Leo Fitz, that Simmons was wearing to investigate the location where Franklin Hall was kidnapped.
 * Electro-Static Field Scanner: Simmons used it in conjunction with the Full-Spectrum Goggles in Colorado, but the scanner activated one of the Gravity Field Generators that where used to kidnap Franklin Hall.
 * Anti-Serum Delivery Mechanism: Leo Fitz developed this device against the clock to deliver the anti-serum Simmons developed to cure the Chitauri Virus she had contracted, applying it on lab rats before being able to apply it on herself.
 * Paranasal Extraction Unit: To retrieve the intel that Agent Shaw gathered in Siberia, Simmons had to extract it from his skull through his nasal cavity, using this device to perform the uncomfortable maneuver.
 * Spectrographic Analyzer: During an investigation in Trillemarka National Park, Simmons had to analyze the spectrographic signatures of a curious marking inside a fallen tree, quickly realizing that they had an extraterrestrial origin even before Leo Fitz determined they were of Asgardian origin.
 * Three Dimensional Scanner: Simmons resorted to use the scanner for a three-dimensional restoration of the imprints inside the tree in Trillemarka National Park,
 * Flex Screen: Simmons kept a Flex Screen during her undercover assignment to infiltrate HYDRA, as a means of contacting Director Phil Coulson in case of need, but she had to get rid of it when HYDRA realized they had a spy within its ranks.
 * Upgraded Cell Phone: Simmons has a specially made cell phone containing an upgraded battery created by Leo Fitz. The upgraded battery allowed the phone to last for weeks without a charge.

Fitz-Simmons Designs
"I'm engineering, she's bio-chem."

- Leo Fitz referring to himself and Jemma Simmons

Family

 * Father
 * Mother

Allies

 * S.H.I.E.L.D. (First Incarnation) - Allies (Former Relationships)
 * Peggy Carter - Role Model and Heroine
 * Nick Fury - Director
 * Maria Hill - Deputy Director
 * Victoria Hand † - Superior Officer
 * Felix Blake - Colleague
 * Eric Koenig † - Colleague
 * Billy Koenig - Colleague
 * Jazuat - Colleague
 * Davis - Colleague
 * Garrett's Team - Colleagues
 * John Garrett †
 * Antoine Triplett †
 * S.H.I.E.L.D. Academy of Science and Technology
 * Anne Weaver - Former Teacher
 * Franklin Hall - Former Teacher
 * Professor Vaughn - Former Teacher
 * Coulson's Team - Teammates
 * Phil Coulson - Team Leader
 * Leo Fitz - Best Friend
 * Melinda May
 * Skye - Friend
 * S.H.I.E.L.D. (Second Incarnation)
 * Phil Coulson - Director
 * Melinda May - Colleague
 * Leo Fitz - Colleague, Best Friend and Love Interest
 * Daisy Johnson - Colleague and Close Friend
 * Antoine Triplett † - Colleague and Friend
 * Lance Hunter - Colleague
 * Bobbi Morse - Colleague and Friend
 * Alphonso Mackenzie - Colleague
 * Billy Koenig - Colleague
 * Sam Koenig - Colleague
 * Michael Peterson - Enemy (while under HYDRA coercion) turned Colleague
 * Robert Gonzales † - Enemy turned Ally
 * Anne Weaver - Former Teacher and Colleague
 * Secret Warriors - Colleagues
 * Lincoln Campbell
 * Joey Gutierrez
 * Akela Amador - Enemy (while under HYDRA coercion) turned Ally
 * Elliot Randolph
 * Sif
 * Will Daniels † - Friend and Lover
 * Advanced Threat Containment Unit - Situational Allies
 * Rosalind Price †
 * Luther Banks †

Enemies

 * Raina †
 * HYDRA
 * Grant Ward † - Former Teammate turned Enemy
 * Jasper Sitwell † - Former S.H.I.E.L.D. Superior
 * Centipede Project
 * John Garrett † - Former S.H.I.E.L.D. Superior
 * Ian Quinn
 * Daniel Whitehall †
 * Sunil Bakshi † - Victim
 * Kenneth Turgeon - Former Friend and Colleague
 * Theo
 * Lingenfelter
 * Gideon Malick
 * Giyera
 * Camilla Reyes
 * Cybertek
 * Carlo Mancini †
 * Lorelei
 * Calvin Zabo
 * Andrew Garner - Ally tuned Enemy
 * It

Trivia

 * According to a deleted scene, Simmons had a one night stand with a guy who went up to her and Skye during a mission at the S.H.I.E.L.D. Academy, and their relationship never went into anything more because he was a bit boring.
 * From the same scene, during her years at the Academy, Simmons did not exactly have boyfriends because she never found anyone as interesting other than Fitz, to whom she refers as being "the only thing interesting in this place".

Behind the Scenes

 * The relationship between Leo Fitz and Simmons is based on the relationship between Jed Whedon and Maurissa Tancharoen.
 * Elizabeth Henstridge shares a birthday with her character Jemma Simmons.
 * Due to her popularity, Jemma Simmons was introduced into the main Marvel Comics universe.