What If...

What If... is the sixteenth episode of the fourth season of the television series Agents of S.H.I.E.L.D.  and the eighty-second episode overall.

Synopsis
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Plot
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Cast
Main Cast:
 * Clark Gregg as Phil Coulson
 * Ming-Na Wen as Melinda May
 * Chloe Bennet as Daisy Johnson/Quake
 * Iain De Caestecker as Leo Fitz
 * Elizabeth Henstridge as Jemma Simmons
 * Henry Simmons as Alphonso Mackenzie
 * John Hannah as Holden Radcliffe

Guest Stars:
 * Brandon Morales as to-be-confirmed
 * Taj Speights as Burnell

Locations
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Events
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Items

 * Phil Coulson's Prosthetic Hand
 * Framework

Vehicles
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Sentient Species

 * Humans
 * Inhumans

Organizations

 * S.H.I.E.L.D.
 * HYDRA

Mentioned
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Trivia

 * The title of the episode is a reference to the Marvel comic series What If? Comic Books. The series took significant events from the Marvel Universe and speculate about what might have happened if it had had a different outcome. Each issue offers a look at characters we know in situations they might never really face.