Framework

"This breakthrough I've made is way beyond that. I call it the Framework. I've built a world where death is obsolete."

- Holden Radcliffe to Agnes Kitsworth

The Framework is a simulation created by Holden Radcliffe and adapted from a S.H.I.E.L.D. development program designed by Leo Fitz.

Prototype
The early prototype of framework was designed by Leo Fitz with the help of Jemma Simmons as a training simulation program as sparring tool for agents serving as a blueprint as a template for animproved version by Radcliffe.

Sedating Melinda May
Holden Radcliffe used the Framework to keep Melinda May from escaping while her Life-Model Decoy had assumed her place. Initially, May experienced getting a massage and facial but she resisted the program, eventually breaking out and fighting Radcliffe and his personal LMD Aida. When Aida overpowered and sedated her Radcliffe reprogrammed the Framework with a simulation where she became stuck in an endless loop of escaping Aida.

Interrogating Billy Koenig
In an attempt to find the Darkhold, Radcliffe allied himself with the Watchdogs to kidnap Billy Koenig who knew where the Darkhold was. To prevent bloodshed, Radcliffe sent Koenig into the Framework where he experienced a puppy. Once the Framework finished mapping Koenig's memories, Radcliffe entered them, discovering that the Darkhold was held in the S.H.I.E.L.D. vault known as the Labyrinth.

A New Reality
Radcliffe eventually redesigned the Framework so the user would be able to correct their greatest regret. Due to the fact that said regret was often a defining moment in the user's life, however, this correction resulted in the user becoming a drastically different person.

Sometime later, Aida captured Fitz, Jeffrey Mace, Phil Coulson and Alphonso Mackenzie before uploading their combined consciousnesses into the Framework.

Following the Siege of the Playground, Daisy Johnson and Jemma Simmons decided to enter the Framework and extract their colleagues, unaware that the changes to each individual's life resulted in the formation of an alternate reality simulation where HYDRA had replaced S.H.I.E.L.D.

Description
The Framework is a simulation where the concept of death is deemed irrelevant. The user enters the Framework through a specialized helmet that uploads their consciousness into the simulation. Once the upload is complete, the Framework adapts to the user's environment through cerebral and physical recalibration.

Appearances
In chronological order:
 * Agents of S.H.I.E.L.D.
 * Season Four
 * The Ghost
 * Uprising
 * Wake Up
 * Hot Potato Soup
 * BOOM
 * The Man Behind the Shield
 * Self Control
 * What If...