Words of Creation

The Alien Equation is an unknown origin equation found inside Todorov Building in Belarus.

History
After Skye hijacked the eye implant signal, the S.H.I.E.L.D. Agent Grant Ward completed Akela Amador's infiltration mission given her by HYDRA, using a set of glasses mimicking her eye implant. He found that the target of the infiltration mission to the was the equation, that was being studied by two men.

After John Garrett was infused with the GH.325 he started displaying insanity behaviour. Questioned by Grant Ward, Garrett told him that he was "alive" and "could do anything" while carving the equation on a glass piece inside the Bus.

Agent Phil Coulson was given the Toolbox by Nick Fury, which led him to the S.H.I.E.L.D. secret facility, the Playground. Later that night, Coulson awakened and began writing the equation on one of the facility walls. Possibly a side effect to the GH.325, the same way it happened to John Garrett.

Trivia

 * Next to the equation seen in Agents of S.H.I.E.L.D. episode 4 Eye-Spy, it is also pieces of Skrull language. In the comics, the Skrull are a shape-shifting race from the Andromeda Galaxy.